中国现代神经疾病杂志 ›› 2013, Vol. 13 ›› Issue (8): 679-682. doi: 10.3969/j.issn.1672-6731.2013.08.006

• 专题讲座 • 上一篇    下一篇

2 帕金森病情绪障碍

李淑华, 陈海波   

  1. 100730 卫生部北京医院神经内科
  • 出版日期:2013-08-25 发布日期:2013-08-04
  • 通讯作者: 陈海波 (Email:chenhbneuro@263.net)
  • 基金资助:

    首都卫生发展科研专项资助项目(项目编号:2011-4011-01)

Emotional impairment in Parkinson's disease

LI Shu-hua, CHEN Hai-bo   

  1. Department of Neurology, Beijing Hospital, Beijing 100730, China
  • Online:2013-08-25 Published:2013-08-04
  • Contact: CHEN Hai-bo (Email: chenhbneuro@263.net)
  • Supported by:

    This study was supported by Capital Health Development Research Foundation Project (No. 2011-4011-01).

摘要: 情绪障碍可以影响帕金森病患者的生活质量及疾病预后。神经心理学测验和神经影像学研究发现,帕金森病患者情绪障碍可能与中脑-边缘系统、中脑-皮质多巴胺能通路损害有关,但具体的病理学机制尚待进一步研究。本文拟就帕金森病患者情绪障碍的临床表现、可能的病理生理学机制、诊断及治疗进行探讨。

关键词: 帕金森病, 情绪障碍, 综述

Abstract: Emotional impairment is the common complication of Parkinson's disease (PD). Depression, anxiety and apathy affect the quality of life and the prognosis of PD patients. Neuropsychological and neuroimaging studies of emotional impairment in PD patients suggest abnormalities involving mesolimbic and mesocortical dopaminergic pathways, but the specific mechanism needs further study. In this review we discuss the clinical manifestation, possible pathological mechanism, diagnosis and treatment in PD patients.

Key words: Parkinson disease, Mood disorders, Review