摘要： 表观遗传学调控通过DNA 甲基化和组蛋白修饰等方式改变DNA 的表达水平，在中枢神经系统退行性疾病中发挥重要作用。目前，越来越多的疾病应用表观遗传学原理研制新型药物，为阿尔茨海默病、帕金森病、亨廷顿病和肌萎缩侧索硬化症等中枢神经系统退行性疾病的治疗提供新的方法。本文主要总结表观遗传学在中枢神经系统退行性疾病中的研究进展，同时探讨以表观遗传学为依据的治疗方法的临床应用。

关键词: 神经变性疾病, 遗传学研究, DNA 甲基化, 组蛋白类, 乙酰化作用, 综述

Abstract: Epigenetics refer to the collective heritable changes in phenotype due to processes that arise independently of primary DNA sequence. It is comprised of DNA methylation, histone proteins modifications, non-coding and so on. Aberrant epigenetic modifications are involved in the development of neurodegenerative disorders. Recently, many epigenetics-based medications have been developed and provided us new strategies for treatment of those diseases, including Alzheimer's disease, Parkinson's disease and Huntington's disease. In this review, we would like to summarize the recent studies of epigenetic modification in neurodegeneration, mainly focusing on DNA methylation and histone acetylation and exploring the possibility of using epigenetics-based therapeutics to treat neurodegenerative disorders.

Key words: Neurodegenerative diseases, Genetic research, DNA methylation, Histones, Acetylation, Review