Progress of NLRP3 inflammasome in the pathogenesis of heart disease

doi:10.16352/j.issn.1001-6325.2023.07.1162

Abstract

Abstract: NLRP3 inflammatsome is the most characteristic inflammasome. It can play some roles in the pathogenesis of heart diseases such as heart failure, myocardial infarction, atherosclerosis and arrhythmia. Inhibiting the activation of NLRP3 inflammasome can effectively treat heart diseases. The assembly and activation process of inflammasome are complex. Revealing its activation process and its relationship with heart disease may develop new drugs targeting at the prevention and treatment of heart disease.

Key words: NLRP3 inflammasome, cardiovascular disease, inflammatory reaction

CLC Number:

R392.12

GAO Yuan, ZHENG Gang, QI Jing, ZHANG Feng. Progress of NLRP3 inflammasome in the pathogenesis of heart disease[J]. Basic & Clinical Medicine, 2023, 43(7): 1162-1166.

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