Research progress on the role of NLRP3 inflammasome in the treatment of ischemia-reperfusion injury

doi:10.16352/j.issn.1001-6325.2023.04.0706

Abstract

Abstract: NOD-like receptor protein 3(NLRP3) inflammasome, as a protein complex that constitutes the innate immune system, can mediate inflammatory responses by regulating the maturation and release of IL-1β and IL-18, which are the basic for multiple pathological injury. A variety of injury factors generated during ischemia-reperfusion injury (I/RI) can activate the NLRP3 inflammasome, resulting in the excessive release of IL-1β and IL-18, which in turn leads to an inflammatory cascade to aggravate the damage of various tissues and organs. Inhibition of NLRP3 inflammasome activation has become an effective method to alleviate organ I/RI. Therefore, exploring the detailed mechanism of NLRP3 inflammasome-mediated I/RI can provide a theoretical basis for the prevention and treatment of organ I/RI.

Key words: NLRP3 inflammasome, ischemia-reperfusion injury, organ protection

CLC Number:

R364.5

LU Yapeng, XIE Jianqin. Research progress on the role of NLRP3 inflammasome in the treatment of ischemia-reperfusion injury[J]. Basic & Clinical Medicine, 2023, 43(4): 706-710.

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