TMEM gene family in tumor development

doi:10.16352/j.issn.1001-6325.2025.09.1243

Abstract

Abstract: The transmembrane protein gene family (TMEM) refers to a group of genes that encode trans-membrane proteins. The TMEM family influences tumor angiogenesis by affecting key signaling pathways involved in angiogenesis, modulating the interactions between tumor cells and endothelial cells and regulating the expression or function of VEGF and its receptor VEGFR. Thereby it may have impact on tumor blood vessel formation. Additionally, the TMEM family regulates mechanisms such as post-translational modifications of histone, which also play a role in tumor initiation and progression. Post-translational modifications of TMEM proteins including phosphorylation, glycosylation, acetylation and palmitoylation. TMEM family contributes to tumorigenesis and may identify some novo targets used in precise medical treatment.

Key words: TMEM, tumor, angiogenesis, post-translational modification of histone

CLC Number:

LING Caixia, WANG Chunfang, LUO Yanhong. TMEM gene family in tumor development[J]. Basic & Clinical Medicine, 2025, 45(9): 1243-1247.

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