Advances on the role of PTTG1 in the pathogenesis of tumors

doi:10.16352/j.issn.1001-6325.2023.09.1448

Abstract

Abstract: Pituitary tumor transforming gene 1(PTTG1) is an oncogene which isolated from the pituitary gland. PTTG1 was previously reported to bind and inhibit separase to affect sister chromatid separation and lead to chromosome aneuploidy, activate the DNA damage response pathway to induce p53-dependent senescence, and also transactivate some oncogenes and promote cell transformation and tumorigenesis in nude mice. It can also promote tumor growth and invasion by affecting Wnt/β-catenin, epithelial-mesenchymal transition(EMT), and TGFβ/SMAD3 pathways. This article provides ideas for the development of tumor therapeutic drugs targeting PTTG1.

Key words: pituitary tumor transforming gene 1(PTTG1), mechanism, tumor

CLC Number:

:R73

WU Nianping, HUANG Huili, ZHOU Kuaile, ZHOU Cefan, TANG Jingfeng. Advances on the role of PTTG1 in the pathogenesis of tumors[J]. Basic & Clinical Medicine, 2023, 43(9): 1448-1452.

References 25

[1]	Yu J, Raia P, Ghent CM, et al. Structural basis of human separase regulation by securin and cdk1-cyclin b1[J]. Nature, 2021, 596: 138-142.
[2]	Perramon M, Carvajal S, Reichenbach V, et al. The pituitary tumour-transforming gene 1/delta-like homologue 1 pathway plays a key role in liver fibrogenesis[J]. Liver Int, 2022, 42: 651-662.
[3]	Perramon M, Jimenez W. Pituitary tumor-transforming gene 1/delta like non-canonical notch ligand 1 signaling in chronic liver diseases[J]. Int J Mol Sci, 2022, 23. doi:10.3390/ijms23136897.
[4]	Lin X, Yang Y, Guo Y, et al. PTTG1 is involved in tnf-alpha-related hepatocellular carcinoma via the induction of c-myc[J]. Cancer Med, 2019, 8: 5702-5715.
[5]	Yang G, Xiog Y, Wang G, et al. miR-374c-5p regulates PTTG1 and inhibits cell growth and metastasis in hepatocellular carcinoma by regulating epithelial-mesenchymal transition[J]. Mol Med Rep, 2022, 25. doi:10.3892/mmr.2022.12664.
[6]	Huang S, Liao Q, Li W, et al. The lncRNA PTTG3p promotes the progression of crpc via upregulating PTTG1[J]. Bull Cancer, 2021, 108: 359-368.
[7]	Zhang Z, Jin B, Jin Y, et al. PTTG1, a novel androgen responsive gene is required for androgen-induced prostate cancer cell growth and invasion[J]. Exp Cell Res, 2017, 350: 1-8.
[8]	Huang S, Liao Q, Li L, et al. PTTG1 inhibits smad3 in prostate cancer cells to promote their proliferation[J]. Tumour Biol, 2014, 35: 6265-6270.
[9]	Cui L, Ren T, Zhao H, et al. Suppression of PTTG1 inhibits cell angiogenesis, migration and invasion in glioma cells[J]. Med Oncol, 2020, 37: 73. doi:10.1007/s12032-020-01398-2.
[10]	Cui L, Xu L, Wang G, et al. Stat3-PTTG11 abrogation inhibits proliferation and induces apoptosis in malignant glioma cells[J]. Oncol Lett, 2020, 20: 6. doi:10.3892/ol.2020.11867.
[11]	Zheng Y, Guo J, Zhou J, et al. Foxm1 transactivates PTTG1 and promotes colorectal cancer cell migration and invasion[J]. BMC Med Genomics, 2015, 8: 49. doi:10.1186/s12920-015-0126-9.
[12]	刘军, 齐秀恒, 武振明, 等. 垂体肿瘤转化基因调控结直肠癌细胞凋亡及其与PI3K/AKT信号通路的关系[J]. 广西医科大学学报, 2020, 37: 2173-2179.
[13]	Qiu M, Li G, Wang P, et al. Aarf domain containing kinase 5 gene promotes invasion and migration of lung cancer cells through adck5-sox9-PTTG1 pathway[J]. Exp Cell Res, 2020, 392: 112002. doi:10.1016/j.yexcr.2020.112002.
[14]	Chen Z, Cao K, Hou Y, et al. PTTG1 knockdown enhances radiation-induced antitumour immunity in lung adenocarcinoma[J]. Life Sci, 2021, 277: 119594. doi:10.1016/j.lfs.2021.119594.
[15]	Wang W, Cao R, Su W, et al. miR-655-3p inhibits cell migration and invasion by targeting pituitary tumor-transforming 1 in non-small cell lung cancer[J]. Biosci Biotechnol Biochem, 2019, 83: 1703-1708.
[16]	Teveroni E, Di Nicuolo F, Vergani E, et al. PTTG1/zeb1 axis regulates e-cadherin expression in human seminoma[J]. Cancers (Basel), 2022, 14. doi:10.3390/cancers14194876.
[17]	Teveroni E, Di Nicuolo F, Bianchetti G, et al. Nuclear localization of PTTG1 promotes migration and invasion of seminoma tumor through activation of mmp-2[J]. Cancers (Basel), 2021, 13. doi:10.3390/cancers13020212.
[18]	Lee SS, Choi JH, Lim SM, et al. Alteration of pituitary tumor transforming gene 1 by microRNA-186 and 655 regulates invasion ability of human oral squamous cell carcinoma[J]. Int J Mol Sci, 2021, 22. doi:10.3390/ijms22031021.
[19]	Chen SW, Zhou HF, Zhang HJ, et al. The clinical significance and potential molecular mechanism of PTTG1 in esophageal squamous cell carcinoma[J]. Front Genet, 2020, 11: 583085. doi:10.3389/fgene.2020.583085.
[20]	Li JD, Farah AA, Huang ZG, et al. Clinical significance and potential regulatory mechanism of overexpression of pituitary tumor-transforming gene transcription factor in bladder cancer[J]. BMC Cancer, 2022, 22: 713. doi:10.1186/s12885-022-09810-y.
[21]	Zhou M, Chen J, Zhang H, et al. Klf10 inhibits cell growth by regulating PTTG1 in multiple myeloma under the regulation of microrna-106b-5p[J]. Int J Biol Sci, 2020, 16: 2063-2071.
[22]	Hu ZG, Zheng CW, Su HZ, et al. MicroRNA-329-mediated PTTG1 downregulation inactivates the mapk signaling pathway to suppress cell proliferation and tumor growth in cholangiocarcinoma[J]. J Cell Biochem, 2019, 120: 9964-9978.
[23]	Hu X, Yang F, Mei H. Pituitary tumor transforming gene 1 promotes proliferation and malignant phenotype in osteosarcoma via NF-KappaB signaling[J]. J Orthop Sci, 2022. doi:10.1016/j.jos.2022.10.020.
[24]	Yin L, He Z, Yi B, et al. Simvastatin suppresses human breast cancer cell invasion by decreasing the expression of pituitary tumor-transforming gene 1[J]. Front Pharmacol, 2020, 11: 574068. doi:10.3389/fphar.2020.574068.
[25]	Guo D, Gu Y, Ma D, et al. A novel microRNA miR-MTCO3P38 inhibits malignant progression via STAT3/PTTG1/MYC in hepatocellular carcinoma[J]. Genes Dis, 2022, 9: 845-848.