Progress of research on the role of exosomes in the occurrence and development of liver precancerous lesions

doi:10.16352/j.issn.1001-6325.2023.09.1453

Abstract

Abstract: Increased secretion of exosomes in precancerous lesions of hepatocellular carcinoma can directly promote the disease from inflammatory response to cancer through intercellular communication. Exosomes participate in the occurrence and development of hepatocellular precancerous lesions by affecting angiogenesis, epithelial-mesenchymal transition and immunoregulation,so exomes may become a new therapeutic target for hepatocellular precancerous lesions and provide new ideas for the diagnosis and treatment of hepatocellular carcinomas.

Key words: exosome, hepatic precancerous lesion, liver cirrhosis, liver fibrosis, macrophage

CLC Number:

R735.7

YANG Yaqian, PAN Yanfang, QU Mengyang, FANG Yan, YING Xiaoping, ZHANG Meiqian, WEI Jing. Progress of research on the role of exosomes in the occurrence and development of liver precancerous lesions[J]. Basic & Clinical Medicine, 2023, 43(9): 1453-1456.

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