Abstract: Objective To find the trends and regional differences of the resistance of Helicobacter pylori(Hp) to metronidazole, clarithromycin, levofloxacin, amoxicillin, furazolidone and tetracycline in recent years in the mainland of China. Methods By searching several databases, the literatures on the resistance of Hp to six commonly prescribed antibiotics in mainland of China were collected and analyzed with Stata15 software. The antibiotic resistance in Huaihe Hospital of Henan University was reviewed and compared. Results The investigation results from 2013 to 2020 showed that rate of Hp metronidazole resistance was the highest and the clarithromycin was the second, while the rate of resistance to amoxicillin was the lowest one. The amoxicillin resistance in the south of China was significantly higher than that in the north of China. The resistance to metronidazole, clarithromycin, levofloxacin and amoxicillin reached (or closed to) the highest level from 2019 to 2020. At present, the resistance to amoxicillin and furazolidone was low and the resistance to clarithromycin was the highest in Huaihe Hospital of Henan University. Conclusions The resistance of Hp to antibiotics in the mainland of China was at a relatively high level. The resistance rate to metronidazole and clarithromycin was high, while that to amoxicillin was low. The antibiotic resistance of HP was more popular in the south of China.

Key words: Helicobacter pylori, antibiotics, drug resistance