An investigation of Helicobacter pylori infection and potential risk factors of colonization found in 10 661 cases from routine physical examination

doi:10.16352/j.issn.1001-6325.2022.01.019

Abstract

Abstract: Objective To investigate the situation of Helicobacter pylori(H.pylori) infection in healthy people and analyze the related risk factors. Methods Retrospective analysis was conducted on 10 661 healthy subjects who underwent carbon 13-urea breath test (¹³C-UBT)on January 1, 2019 to December 30, 2020 in affiliated hospital of North Sichuan Medical College. According to the infection status of Helicobacter pylori (H.pylori), the subjects were divided into H.pylori positive group and H.pylori negative group. H.pylori infection and platelet (PLT), triglyceride(TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG), T3, T4, TSH and pepsinogen Ⅰ (pepsinogen Ⅰ) were analyzed. PepsinogenⅠ, pepsinogen Ⅱ(pepsinogen), gastrin 17(G-17), homocysteine (Hcy), uric acid (UA) and total bilirubin (TBIL)were also examined. Results 1)The total number of positive infections: 4 382, the total positive rate: 41.10%, including 2 717 male positive cases with morbidity as 25.49%. There were 1 665 cases of positive infection in females, and the morbidity was 15.62%, which was lower than that in males (P＜0.05). 2)Compared with the negative group, the age of the positive group was slightly lower than that of the negative group (P＜0.05), and the HDL-C, pepsinogen Ⅰ/Ⅱ, Hcy and TBil were all lower than those of the negative group (P＜0.05). BMI, SBP, DBP, TG, FBG, pepsinogen Ⅰ, pepsinogen and G-17 in H.pylori positive group were all higher than those in negative group (P＜0.05). 3)DOB value was correlated with age, FBG, pepsinogen Ⅰ, pepsinogen, G-17, pepsinogen Ano/Cha and TBil (P＜0.001). 4) The parameters P＜0.05 were further included in binary Logistic regression analysis, and male, BMI, FBG, pepsinogen Ⅱ, pepsinogen branch/root were risk factors for H.pylori infection (P＜0.05). Conclusions H.pylori infection is more common in male population, BMI, FBG, pepsinogen Ⅱ, pepsinogen L/N are the risk factors for H.pylori infection. Early intervention of these risk factors is expected to reduce the infection of H.pylori and provide theoretical basis for the primary prevention of this gastrointestinal diseases.

Key words: Helicobacter pylori, carbon13-urea breath test (¹³C-UBT), risk factors, correlation

CLC Number:

R543.5

LEI Rong, YANG Dan, YUAN Fang-tao, ZHOU Xiao-yan, JIANG Yi-min, LIU Mi. An investigation of Helicobacter pylori infection and potential risk factors of colonization found in 10 661 cases from routine physical examination[J]. Basic & Clinical Medicine, 2022, 42(1): 126-130.

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