Basic & Clinical Medicine ›› 2025, Vol. 45 ›› Issue (1): 130-134.doi: 10.16352/j.issn.1001-6325.2025.01.0130

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Mechanism of spasmolytic polypeptide-expressing metaplasia in gastric mucosa induced by Helicobacter pylori infection

WANG Hainuo1, LI Yufan1, WANG Yuying2, SHEN Qianying3, ZHU Jinxia3, ZHENG Lifei3*   

  1. 1. Department of Grade 2020 Five-year Clinical Medicine; 2. Department of Grade 2020 Five-year Basic Medicine; 3. Department of Physiology and Pathophysiology, Basic Medical College, Capital Medical University, Beijing 100069, China
  • Received:2024-05-21 Revised:2024-07-08 Online:2025-01-05 Published:2024-12-25
  • Contact: *13581582937@163.com

Abstract: Helicobacter pylori(H. pylori) infection triggers gastric mucosal inflammatory responses and spasmolytic polypeptide-expressing metaplasia (SPEM). These pathological conditions can escalate the severity of chronic gastritis, gastric ulcers and even cause gastric cancer. SPEM is frequently viewed as an early sign of gastric mucosal injury and the onset of carcinogenesis. A comprehensive analysis of the genesis and molecular regulation of SPEM cells in the context of H. pylori infection further has enlightened the pathogenesis of gastric mucosal diseases and provide new ideas and targets for diagnosing and treatment of H. pylori-related gastric mucosal diseases. This paper reviews a variety of molecular biomarkers associated with SPEM, encompassing TFF2, CD44v9, and AQP5, and delineates their pivotal regulatory functions in H.pylori infection and SPEM. This paper also reviews the origination of SPEM cells and pertinent molecular regulatory mechanisms.

Key words: Helicobacter pylori, spasmolytic polypeptide-expressing metaplasia

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