Abstract: Dental pulp stem cells (DPSC) are mesenchymal stem cells that present in dental pulp cavity, with high self-renewal ability and multi-lineage differentiation potential, showing good prospects to use in regenerative medicine. However, current research on mechanisms and measures of inducing differentiation of dental pulp stem cells is insufficient. Advance of research on osteo/odontogenic differentiation regulation methods of dental pulp stem cells in recent years is reviewed and compared in this article.

Key words: Dental pulp stem cell, dentin, regeneration, differentiation, regulation