Abstract: Microtubule unstable protein, due to its unique microtubule depolymerization activity, it plays an important role in cell proliferation, differentiation and tumorigenesis. In recent years, it has attracted much attention on abnormal expression of microtubule unstable protein in digestive system tumors. Studies found that its over-expression was positively correlated with the degree of differentiation, depth of invasion, the presence of lymph node metastasis or advanced TNM stage in digestive system tumors.

Key words: stathmin1, digestive system tumors, expression, regulation