Association of MICA and CXCR1 with prognosis in children with severe pneumonia

doi:10.16352/j.issn.1001-6325.2026.02.0261

Abstract

Abstract: Objective To investigate the relationship between serum levels of major histocompatibility complex class Ⅰ chain-related molecule A (MICA) and C-X-C motif chemokine receptor 1 (CXCR1) and the immune function and clinical prognosis of children with severe pneumonia. Methods A total of 202 children with severe pneumonia who visited Baoding Hospital, Beijing Children's Hospital Capital Medical University from January 2021 to January 2024 were enrolled as research group, which were divided into good prognosis group and poor prognosis group according to the 28-day prognosis. Another 202 healthy children who underwent physical examination during the same period were included as control group. ELISA was applied to measure the levels of serum MICA and CXCR1. Correlation was analyzed by Pearson's method. Multivariate Logistic regression was applied to analyze the factors influencing the prognosis of children. Receiver operating characteristic (ROC) curves were plotted to analyze the predictive value of serum MICA and CXCR1 for poor prognosis in children. Results Compared with the control group, the research group showed a decrease in CD4⁺T and CD4⁺T/CD8⁺T (P＜0.05), and an increase in CD8⁺T, and the serum MICA and CXCR1 levels (P＜0.05).The serum MICA and CXCR1 levels in children with severe pneumonia was correlated with CD4⁺T, CD8⁺T and CD4⁺T/CD8⁺T (P＜0.05). There were significant differences in the levels of CD4⁺T, CD8⁺T, CD4⁺T/CD8⁺T, MICA and CXCR1 between the poor prognosis group and the good prognosis group (P＜0.05), all of which were prognostic factors of children with severe pneumonia. The area under the curve (AUC) of combined prediction of serum MICA and CXCR1 was 0.909, which was greatly larger than that of MICA (Z=2.337, P=0.019) and CXCR1 (Z=2.555, P=0.011) alone. Conclusions Serum MICA and CXCR1 levels are increased in children with severe pneumonia, and associated with immune function and prognosis. The combination of the two has high prognostic evaluation value.

Key words: severe pneumonia, major histocompatibility complex class Ⅰ chain-related molecule A(MICA), C-X-C motif chemokine receptor 1(CXCR1), immune function, prognosis

CLC Number:

R725.6

WANG Tianjiao, SONG Yiqin, WANG Jing. Association of MICA and CXCR1 with prognosis in children with severe pneumonia[J]. Basic & Clinical Medicine, 2026, 46(2): 261-266.

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