Correlation between serum PLR, SII, and Cys C levels and the vascular recanalization after mechanical thrombectomy in patients with acute cerebral infarction due to large vessel occlusion

doi:10.16352/j.issn.1001-6325.2026.02.0256

Abstract

Abstract: Objective To investigate the correlation and significance of the ratio of serum platelet to lymphocyte count ratio(PLR), systemic inflammatory response index (SII), cystatin C (Cys C) in blood with the degree of vascular recanalization in patients with acute cerebral infarction due to large vessel occlusion after mechanical thrombectomy. Methods Two hundred patients with acute cerebral infarction due to large vessel occlusion were admitted to Nanyang Central Hospital from April 2021 to May 2024 were selected. They were categorized into a complete group and an incomplete group based on whether the blood vessel reopened completely after thrombectomy. The baseline data, preoperative PLR, SII, and Cys C levels were compared between the two groups. The correlation betweenPLR, SII, and Cys C and the degree of blood vessel reopening after thrombectomy, as well as their predictive value for complete blood vessel reopening, were analyzed. Results The proportion of patients with incomplete group high thrombus burden, puncture to recanalization time, PLR, SII, and Cys C were higher in the complete group(P＜0.05); Spearman correlation analysis showed that PLR, SII, and Cys C were negatively correlated with the degree of vascular recanalization (P＜0.001); partial correlation analysis, after adjusting for confounding factors, showed that PLR, SII, and Cys C remained significantly correlated with the degree of vascular recanalization after thrombectomy (P＜0.001); ROC analysis showed that among single factors, Cys C had the highest AUC for predicting complete vascular recanalization, and the AUC of PLR+SII+Cys C was greater than that of Cys C (P＜0.05). Conclusions PLR, SII, and Cys C are associated with the degree of vascular recanalization after mechanical thrombectomy in patients with acute cerebral infarction due to large vessel occlusion, which are potential markers for predicting the degree of vascular recanalization. The combined detection of the three can further improve predictive performance, providing important reference information for early clinical prediction of reflow conditions and treatment.

Key words: PLR, SII, Cys C, acute cerebral infarction with large vessel occlusion, vascular recanalization

CLC Number:

R743.3

PEI Shuang, SUN Jun, WANG Ning, ZHANG Qi, ZHANG Zaihang, BAI Fanghui, WEN Changming. Correlation between serum PLR, SII, and Cys C levels and the vascular recanalization after mechanical thrombectomy in patients with acute cerebral infarction due to large vessel occlusion[J]. Basic & Clinical Medicine, 2026, 46(2): 256-260.

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