脑类器官在药物研发中的研究进展

doi:10.16352/j.issn.1001-6325.2024.09.1208

基础医学与临床 ›› 2024, Vol. 44 ›› Issue (9): 1208-1213.doi: 10.16352/j.issn.1001-6325.2024.09.1208

• 特邀专题：类器官及其芯片 • 上一篇下一篇

脑类器官在药物研发中的研究进展

王靓², 夏隆阔^1,2, 张建民^1,2,3*

1.中国医学科学院基础医学研究所北京协和医学院基础学院免疫学系,北京 100005;
2.国典(北京)医药科技有限公司,北京 100176;
3.常州西太湖细胞治疗前沿技术研究院,江苏常州 213000

收稿日期:2024-06-26 修回日期:2024-07-10 出版日期:2024-09-05 发布日期:2024-08-30
通讯作者: ^*jzhang42@163.com
基金资助:
中国医学科学院医学与健康科技创新工程项目(2021-I2M-1-005,2021-I2M-1-035);北京市科技计划项目(Z231100004823031)

Research progress of brain organoids in drug development

WANG Liang², XIA Longkuo^1,2, ZHANG Jianmin^1,2,3*

1. Department of Immunology, Institute of Basic Medical Sciences CAMS, School of Basic Medicine PUMC, Beijing 100005;
2. Guodian Pharmaceutics Ltd., Beijing 100176;
3. Changzhou Xitaihu Institute for Frontier Technology of Cell Therapy, Changzhou 213000, China

Received:2024-06-26 Revised:2024-07-10 Online:2024-09-05 Published:2024-08-30
Contact: ^*jzhang42@163.com

摘要/Abstract

摘要： 近年来,随着再生医学与组织工程学的飞速发展,脑类器官作为一种创新的体外模型系统,逐渐成为神经科学研究和药物研发领域的热点。脑类器官通过模拟人类大脑的复杂结构和功能,在体外重现了大脑发育的关键过程,为理解神经系统疾病机制、评估药物疗效及毒性提供了前所未有的平台。本文综述了脑类器官技术的最新进展,特别是其在药物研发中的应用,并探讨了该领域面临的挑战与未来发展方向。

关键词: 脑类器官, 疾病模型, 药物筛选, 精准治疗

Abstract: In recent years, with rapid development of technology of regenerative medicine and tissue engineering, brain organoids, as an innovative in vitro model system, have become a hot spot in neuroscience research and drug development. Brain organoids simulate the complex structure and function of the human brain in terms of reproducing key processes of brain development in vitro, providing an unprecedented platform for understanding the mechanisms of neurological diseases and of evaluating drug efficacy and toxicity. This review summarizes the latest research progress in brain organoid technology, particularly its application in drug development and in exploring challenges and orientation of future development.

Key words: brain organoids, disease model, drug screening, precision therapy

中图分类号:

Q819

王靓, 夏隆阔, 张建民. 脑类器官在药物研发中的研究进展[J]. 基础医学与临床, 2024, 44(9): 1208-1213.

WANG Liang, XIA Longkuo, ZHANG Jianmin. Research progress of brain organoids in drug development[J]. Basic & Clinical Medicine, 2024, 44(9): 1208-1213.

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脑类器官在药物研发中的研究进展

Research progress of brain organoids in drug development

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