基础医学与临床 ›› 2024, Vol. 44 ›› Issue (9): 1214-1218.doi: 10.16352/j.issn.1001-6325.2024.09.1214

• 特邀专题:类器官及其芯片 • 上一篇    下一篇

肿瘤类器官临床前转化研究及应用

夏雨佳, 杨振丽, 刘玉琴*   

  1. 中国医学科学院基础医学研究所 北京协和医学院基础学院 病理学系,北京 100005
  • 收稿日期:2024-06-26 修回日期:2024-07-10 出版日期:2024-09-05 发布日期:2024-08-30
  • 通讯作者: *liuyuqin@pumc.edu.cn
  • 基金资助:
    中国医学科学院医学与健康科技创新工程-重大协同创新项目(2021-I2M-1-053)

Preclinical translational research and application of tumor organoids

XIA Yujia, YANG Zhenli, LIU Yuqin*   

  1. Department of Pathology, Institute of Basic Medical Sciences CAMS, School of Basic Medicine PUMC, Beijing 100005, China
  • Received:2024-06-26 Revised:2024-07-10 Online:2024-09-05 Published:2024-08-30
  • Contact: *liuyuqin@pumc.edu.cn

摘要: 越来越深入的肿瘤机制研究和临床精准治疗对肿瘤模型的建立提出了更高的要求,肿瘤类器官应用越来越广泛。该模型被认为可以再现亲代肿瘤的基因组、转录组、蛋白质组等多组学特征,具有细胞系模型所缺乏的异质性。基于这些特征,肿瘤类器官逐渐成为一个具有代表性的临床前模型,助力于新的研究成果转化以及患者的精准治疗。本文将从肿瘤类器官的研究及应用的角度总结其最新进展,重点关注当前建立肿瘤类器官方法以及应用中所面临的机遇和挑战。

关键词: 肿瘤类器官, 精准治疗, 类器官生物样本库

Abstract: More and more in-depth tumor mechanism research and clinical precision treatment have put forward higher requirements for the technology for the establishment of tumor models.More and more tumor organoids have been applied. This model is able to reproduce the genomic, transcriptome, proteome and other omics features of parental tumors without heterogeneity found in cell line models. Based on these characteristics, tumor organoids have gradually become a representative preclinical model, facilitating the translation of new research results and precision treatment of patients. This article summarizes the latest progress of tumor organoids on R&D of technology and application, focusing on the current methods of establishing tumor organoids, opportunities and challenges in clinical and research application.

Key words: tumor organoid, precise treatment, organoid biobank

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