器官芯片——更具前景的体外模型

doi:10.16352/j.issn.1001-6325.2024.09.1202

基础医学与临床 ›› 2024, Vol. 44 ›› Issue (9): 1202-1207.doi: 10.16352/j.issn.1001-6325.2024.09.1202

• 特邀专题：类器官及其芯片 • 上一篇下一篇

器官芯片——更具前景的体外模型

杨振丽, 夏雨佳, 刘玉琴^*

中国医学科学院基础医学研究所北京协和医学院基础学院病理学系,北京 100005

收稿日期:2024-06-26 修回日期:2024-07-10 出版日期:2024-09-05 发布日期:2024-08-30
通讯作者: ^*liuyuqin@pumc.edu.cn
基金资助:
中国医学科学院医学与健康科技创新工程-重大协同创新项目(2021-I2M-1-053)

Organ-on-a-chip: a more promising in vitro model

YANG Zhenli, XIA Yujia, LIU Yuqin^*

Department of Pathology, Institute of Basic Medical Sciences CAMS, School of Basic Medicine PUMC, Beijing 100005, China

Received:2024-06-26 Revised:2024-07-10 Online:2024-09-05 Published:2024-08-30
Contact: ^*liuyuqin@pumc.edu.cn

摘要/Abstract

摘要： 传统的体外模型具有不可避免的局限性,与人体试验相比,在评估药物疗效和不良反应方面存在显著差异。器官芯片技术在生理环境和功能芯片上模拟人体器官,具有高保真的生理或病理生理功能,为药物开发提供了巨大的创新前景。本文主要从体内各系统角度介绍器官芯片的研究进展和应用,同时提出目前器官芯片发展过程中存在的局限性和未来的发展方向。

关键词: 器官芯片, 类器官, 疾病模型

Abstract: Traditional in vitro models have inevitable limitations and there are significant differences in assessing drug efficacy and side effects as compared to human trials. Organ-on-a-chip technology simulates human organs in a physiological environment and functional chip with a high fidelity physiological or pathophysiological level, offering great innovative prospects for drug development. This paper mainly introduces the research progress and application of organ chip from the perspective of various systems in vivo. At the same time, the limitations of the current development process of organ chip and the future development direction are proposed.

Key words: organ-on-a-chip, organoid, disease model

中图分类号:

R318.19

杨振丽, 夏雨佳, 刘玉琴. 器官芯片——更具前景的体外模型[J]. 基础医学与临床, 2024, 44(9): 1202-1207.

YANG Zhenli, XIA Yujia, LIU Yuqin. Organ-on-a-chip: a more promising in vitro model[J]. Basic & Clinical Medicine, 2024, 44(9): 1202-1207.

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器官芯片——更具前景的体外模型

Organ-on-a-chip: a more promising in vitro model

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