结直肠肿瘤差异表达RNA在疾病中作用的研究进展

doi:10.16352/j.issn.1001-6325.2022.10.1616

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (10): 1616-1620.doi: 10.16352/j.issn.1001-6325.2022.10.1616

结直肠肿瘤差异表达RNA在疾病中作用的研究进展

李双, 李洋^*

哈尔滨医科大学附属第二医院风湿免疫科,黑龙江哈尔滨 150000

收稿日期:2021-05-17 修回日期:2021-10-09 出版日期:2022-10-05 发布日期:2022-09-23
通讯作者: * liyanghmu@163.com

Research progress on the role of colon rectal neoplasia differentially expressed RNA in diseases

LI Shuang, LI Yang^*

Department of Rheumatology and Immunology, the Second Affiliated Hospital of Harbin Medical University, Harbin 150000, China

Received:2021-05-17 Revised:2021-10-09 Online:2022-10-05 Published:2022-09-23
Contact: * liyanghmu@163.com

摘要/Abstract

摘要： 结直肠肿瘤差异表达(CRNDE)RNA是一种长非编码RNA,可在转录、转录后及翻译水平等多个层面调节基因表达,在多种生理和病理过程中发挥作用。CRNDE参与结直肠肿瘤、胶质瘤、肝细胞癌等肿瘤疾病、肺炎和脓毒症等炎性反应以及糖尿病心肌病和骨质疏松等多种疾病的发展和预后,有望成为新的生物标志物或治疗靶点。

关键词: 结直肠肿瘤差异表达, 肿瘤, 炎性反应

Abstract: Colon rectal neoplasia differentially expressed (CRNDE) RNA is a long non-coding RNA molecule that regulates gene expression at multiple levels including transcriptional, post-transcriptional and translational levels, plays a role in a variety of physiological and pathological processes. CRNDE is involved in the development and prognosis of colorectal tumors, glioma, hepatocellular carcinoma and other tumor diseases, inflammatory response such as pneumonia and sepsis, diabetic cardiomyopathy and osteoporosis. So it is expected to be a new biomarker or therapeutic target.

Key words: colon rectal neoplasia differentially expressed, tumor, inflammation

中图分类号:

李双, 李洋. 结直肠肿瘤差异表达RNA在疾病中作用的研究进展[J]. 基础医学与临床, 2022, 42(10): 1616-1620.

LI Shuang, LI Yang. Research progress on the role of colon rectal neoplasia differentially expressed RNA in diseases[J]. Basic & Clinical Medicine, 2022, 42(10): 1616-1620.

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结直肠肿瘤差异表达RNA在疾病中作用的研究进展

Research progress on the role of colon rectal neoplasia differentially expressed RNA in diseases

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