评估老年衰弱相关血清生物学标志物的研究进展

doi:10.16352/j.issn.1001-6325.2022.04.018

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (4): 646-650.doi: 10.16352/j.issn.1001-6325.2022.04.018

评估老年衰弱相关血清生物学标志物的研究进展

戴靖榕^1,2, 李婕^1,2, 何旭^1,2, 李燕^1,2*

1.昆明理工大学医学院, 云南昆明 650500;
2.云南省第一人民医院老年医学科, 云南昆明 650032

收稿日期:2021-07-28 修回日期:2021-11-11 出版日期:2022-04-05 发布日期:2022-04-01
通讯作者: * liyanken@126.com
基金资助:
国家自然科学基金(81760109);国家重点研发计划(2018YFC2002103);云南省卫生科技计划(2017NS221,2017NS222); 云南省临床医学开发项目(2019LCZXKF-NM08,2021LCZXXF-NM09);云南省老年疾病临床医学研究中心——老年共病治疗及临床转化研究(202102AA310068);云南省董碧蓉专家工作站(202105AF150032)

Research progress on assessment of serum biomarkers related to senile frailty

DAI Jing-rong^1,2, LI Jie^1,2, HE Xu^1,2, LI Yan^1,2*

1. School of Medicine, Kunming University of Science and Technology,Kunming 650500;
2. Department of Geriatrics, the First People's Hospital of Yunnan Province, Kunming 650032,China

Received:2021-07-28 Revised:2021-11-11 Online:2022-04-05 Published:2022-04-01
Contact: * liyanken@126.com

摘要/Abstract

摘要： 当前关于老年衰弱的评估仍然采用量表及问卷形式,这种主观的评估方式易随评估人员及评估量表的不同而产生较大差异,因此,探寻衰弱的客观诊断依据显得尤为重要。随着人群队列和观察性研究的不断展开,老年衰弱在血清学方面取得较大进展。本文主要从血清炎性因子、激素、维生素、同型半胱氨酸及相关蛋白分子对衰弱的影响机制进行综述,为进一步探索老年衰弱的客观诊断依据提供新思路。

关键词: 衰弱, 生物学标志物, 机制, 老年

Abstract: The assessment of senile frailty still implemented with scales and questionnaires. This subjective assessment method is prone to vary greatly with the assessors and scales. Therefore, it is particularly important to explore the Objective diagnosis basis of frailty.With the continuous development of population cohort and observational studies, great progress has been made in the serology of senile frailty.This article mainly reviews the influence mechanism of serum inflammatory factors, hormones, vitamins, homocysteine and related protein molecules on frailty and provides new ideas to further exploring the Objective diagnosis basis of frailty in the elderly.

Key words: frailty, biological markers, mechanism, aged

中图分类号:

R592

戴靖榕, 李婕, 何旭, 李燕. 评估老年衰弱相关血清生物学标志物的研究进展[J]. 基础医学与临床, 2022, 42(4): 646-650.

DAI Jing-rong, LI Jie, HE Xu, LI Yan. Research progress on assessment of serum biomarkers related to senile frailty[J]. Basic & Clinical Medicine, 2022, 42(4): 646-650.

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评估老年衰弱相关血清生物学标志物的研究进展

Research progress on assessment of serum biomarkers related to senile frailty

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