雌激素及其受体在克罗恩病发生和发展中作用的研究进展

doi:10.16352/j.issn.1001-6325.2022.03.017

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (3): 494-497.doi: 10.16352/j.issn.1001-6325.2022.03.017

雌激素及其受体在克罗恩病发生和发展中作用的研究进展

武国智^1,2, 安丽娜^1,2, 刘敏^1,2, 王玉平^1,2, 郭庆红^1,2*

1.兰州大学第一临床医学院,甘肃兰州 730000;
2.兰州大学第一医院消化科甘肃省胃肠病重点实验室,甘肃兰州 730000

收稿日期:2020-10-22 修回日期:2021-04-06 出版日期:2022-03-05 发布日期:2022-03-04
通讯作者: ^* guoza@sohu.com
基金资助:
国家重点研发计划(2016YFC0107006);国家自然科学基金(81960430);甘肃省自然科学基金(21JR1RA117);兰州大学第一医院院内基金(ldyyyn2018-38);

Research progress on estrogen and its receptors in occurrence and advance of Crohn's disease

WU Guo-zhi^1,2, AN Li-na^1,2, LIU Min^1,2, WANG Yu-ping^1,2, GUO Qing-hong^1,2*

1. The First Clinical Medical College, Lanzhou University, Lanzhou 730000;
2. Department of Gastroenterology, Key Laboratory of Gastrointestinal Diseases of Gansu Province, the First Hospital of Lanzhou University,Lanzhou 730000, China

Received:2020-10-22 Revised:2021-04-06 Online:2022-03-05 Published:2022-03-04
Contact: ^* guoza@sohu.com

摘要/Abstract

摘要： 克罗恩病(CD)的发生与内分泌系统的调节紊乱相关,其中雌激素及其受体的失调在CD的发病机制中扮演着重要的作用。研究发现雌激素可以下调相关炎性因子的表达,适当地补充雌激素有助于减轻炎性反应程度。而其受体(GPER、ERα和ERβ)表达也在局部免疫反应方面起作用,三者表达水平的失调介导肠道炎性反应的发生。结合目前的研究来看,雌激素及其受体有望成为研究CD发生发展的新方向。

关键词: 克罗恩病, 炎性肠病, 雌激素, 受体, 机制

Abstract: Crohn's disease (CD) is a subtype of inflammatory bowel diseases and may be resulted from endocrine disorders. Estrogen and its receptors exert an important role in the pathogenesis of CD. Studies have revealed that estrogen can down-regulate the expression of inflammatory mediators while estrogen supplementation helps reduce the severity of inflammatory response. The expression of receptors (GPER, ERα and ERβ) also influence local immune responses, and the imbalance of them mediate intestinal inflammation. Nowadays, estrogen and its receptors are expected to become a new rarget in the research of CD.

Key words: Crohn's disease, inflammatory bowel disease, estrogen, receptor, mechanism

中图分类号:

R574

武国智, 安丽娜, 刘敏, 王玉平, 郭庆红. 雌激素及其受体在克罗恩病发生和发展中作用的研究进展[J]. 基础医学与临床, 2022, 42(3): 494-497.

WU Guo-zhi, AN Li-na, LIU Min, WANG Yu-ping, GUO Qing-hong. Research progress on estrogen and its receptors in occurrence and advance of Crohn's disease[J]. Basic & Clinical Medicine, 2022, 42(3): 494-497.

参考文献

[1]Mao R, Kurada S, Gordon I, et al. The mesenteric fat and intestinal muscle interface: creeping fat influencing stricture formation in Crohn's disease[J]. Inflamm Bowel Dis, 2019, 25: 421-426.
[2]Thomann A, Reindl W, Wüstenberg T, et al. Aberrant brain structural large-scale connectome in Crohn's disease[J]. Neurogastroenterol Motil, 2019, 31. doi: 10.1111/nmo.13593.
[3]关玉霞, 尤丽丽, 王田田, 等. 炎性肠病患者知觉压力和应对方式与抑郁水平的相关性[J]. 基础医学与临床, 2019, 39: 1623-1626.
[4]陈丹, 李骥, 张鑫垚, 等. 克罗恩病患者维生素D水平与细胞因子的相关性研究[J]. 中华医学杂志, 2020,100: 757-762.
[5]Shah SC, Khalili H, Gower-Rousseau C, et al. Sex-based differences in incidence of inflammatory bowel diseases-pooled analysis of population-based studies from western countries[J]. Gastroenterology, 2018, 155: 1079-1089.
[6]Shah SC, Khalili H, Chen CY, et al. Sex-based differ-ences in the incidence of inflammatory bowel diseases-pooled analysis of population-based studies from the Asia-Pacific region[J]. Aliment Pharmacol Ther, 2019, 49: 904-911.
[7]Kravdal O, Magnus P, Moum B, et al. Association of childbearing with a short-term reduced risk of Crohn disease in mothers[J]. Am J Epidemiol, 2020, 189: 294-304.
[8]Cook LC, Hillhouse AE, Myles MH, et al. The role of estrogen signaling in a mouse model of inflammatory bowel disease: a helicobacter hepaticus model[J]. PLoS One, 2014, 9. Doi: 10.1371/journal.pone.0094209.
[9]Jacenik D, Zielińska M, Michlewska S, et al. Visualiza-tion of estrogen receptors in colons of mice with tnbs-induced Crohn's disease using immunofluorescence[J]. J Vis Exp, 2020. doi: 10.3791/60813.
[10]Van der Giessen J, Van der Woude CJ, Peppelenbosch MP, et al. A direct effect of sex hormones on epithelial barrier function in inflammatory bowel disease models[J]. Cells, 2019, 8: 261-273.
[11]Liu JM, Yu CP, Chuang HC, et al. Androgen deprivation therapy for prostate cancer and the risk of autoimmune diseases[J]. Prostate Cancer Prostatic Dis, 2019, 22: 475-482.
[12]Lahat A, Falach-Malik A, Haj O, et al. Change in bowel habits during menstruation: are IBD patients different?[J]. Therap Adv Gastroenterol, 2020, 13. doi: 10.1177/1756284820929806.
[13]Rolston VS, Boroujerdi L, Long MD, et al. The influence of hormonal fluctuation on inflammatory bowel disease symptom severity-a cross-sectional cohort study[J]. Inflamm Bowel Dis, 2018, 24: 387-393.
[14]Lachowski D, Cortes E, Matellan C, et al. G protein-coupled estrogen receptor regulates actin cytoskeleton dynamics to impair cell polarization[J]. Front Cell Dev Biol, 2020, 8. doi: 10.3389/fcell.2020.592628.
[15]Liu J, Lin G, Fang M, et al. Localization of estrogen receptor ERα, ERβ and GPR30 on myenteric neurons of the gastrointestinal tract and their role in motility[J]. Gen Comp Endocrinol, 2019, 272: 63-75.
[16]Jacenik D, Cygankiewicz AI, Mokrowiecka A, et al. Sex- and age-related estrogen signaling alteration in inflammatory bowel diseases: modulatory role of estrogen receptors[J]. Int J Mol Sci, 2019, 20. doi: 10.3390/ijms20133175.
[17]Linares P, Algaba A, Urzainqui A, et al. Ratio of circulating estrogen receptors beta and alpha (ERβ/ERα) indicates endoscopic activity in patients with Crohn's disease[J]. Dig Dis Sci, 2017, 62: 2744-2754.
[18]Jacenik D, Cygankiewicz AI, Fichna J, et al. Estrogen signaling deregulation related with local immune response modulation in irritable bowel syndrome[J]. Mol Cell Endocrinol, 2018, 471: 89-96.
[19]Zimmerman MA, Ogola BO, Wilkinson MM, et al. Medroxyprogesterone opposes estradiol-induced renal damage in midlife ovariectomized long evans rats[J]. Menopause, 2020, 27: 1411-1419.
[20]Pelekanou V, Kampa M, Kiagiadaki F, et al. Estrogen anti-inflammatory activity on human monocytes is mediated through cross-talk between estrogen receptor ERα36 and GPR30/GPER1[J]. J Leukoc Biol, 2016, 99: 333-347.
[21]Cabas I, Rodenas M, Abellán E, et al. Estrogen signal-ing through the G protein-coupled estrogen receptor regulates granulocyte activation in fish[J]. J Immunol, 2013, 191: 4628-4639.
[22]Xiao L, Luo Y, Tai R, et al. Estrogen receptor β suppresses inflammation and the progression of prostate cancer[J]. Mol Med Rep, 2019, 19: 3555-3563.
[23]Goodman W, Bedoyan S, Havran H, et al. Impaired estrogen signaling underlies regulatory T cell loss-of-function in the chronically inflamed intestine[J]. Proc Natl Acad Sci U S A, 2020, 117: 17166-17176.
[24]Goodman W, Havran H, Quereshy H, et al. Estrogen receptor α loss-of-function protects female mice from dss-induced experimental colitis[J]. Cell Mol Gastroenterol Hepatol, 2018, 5: 630-633.
[25]Braniste V, Leveque M, Buisson-Brenac C, et al. Oestradiol decreases colonic permeability through oestrogen receptor beta-mediated up-regulation of occludin and junctional adhesion molecule-A in epithelial cells[J]. J Physiol, 2009, 587: 3317-3328.
[26]Li HX, Chen H, Chen L, et al. Expression of oestrogen receptor beta was negatively correlated with disease activity in patients with Crohn's disease involving the terminal ileum[J]. Steroids, 2019,141: 36-40.

雌激素及其受体在克罗恩病发生和发展中作用的研究进展

Research progress on estrogen and its receptors in occurrence and advance of Crohn's disease

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	苏凌峰, 王虎霞, 王延峰, 宋张骏. 慢性压力对乳腺癌发展的影响[J]. 基础医学与临床, 2024, 44(9): 1303-1307.
[2]	彭晴怡, 许岭翎. 1型糖尿病诱发肌少症的研究进展[J]. 基础医学与临床, 2024, 44(8): 1189-1193.
[3]	高艺丹, 蒋雪涵, 张红, 杨沛然. 靶向异常通路的动脉性肺动脉高压新型药物研发[J]. 基础医学与临床, 2024, 44(8): 1088-1093.
[4]	郁冬玲, 莫少娥, 傅文, 陈实, 谢酬勤, 蓝雨雁. 抑制sigma-1受体可减少神经病理性疼痛大鼠DRG细胞凋亡[J]. 基础医学与临床, 2024, 44(8): 1101-1106.
[5]	姚安军, 陈凌子, 金惠仙. 二十二碳六烯酸抑制人结肠癌细胞系HT-29增殖[J]. 基础医学与临床, 2024, 44(8): 1107-1112.
[6]	李佩娟, 王春梅, 赵茜. 三七总皂苷预防血栓的机制[J]. 基础医学与临床, 2024, 44(7): 912-915.
[7]	刘晶华, 卢琳. 肾上腺皮质癌基因及分子机制[J]. 基础医学与临床, 2024, 44(6): 748-752.
[8]	宋丽丽, 管玉洁, 马平, 李宁. 急性髓系白血病患儿柔红霉素耐药与PD-L1蛋白表达相关[J]. 基础医学与临床, 2024, 44(6): 833-839.
[9]	李盈辉, 许依, 张建民, 陈慧, 何维. 靶向BCMA的CAR-γδT细胞抗多发性骨髓瘤的疗效[J]. 基础医学与临床, 2024, 44(6): 763-771.
[10]	刘潇, 王曌慧, 魏心怡, 周玥, 赵丽, 王玥, 李俊发. 糖尿病合并TREM2突变相关认知功能障碍的生物信息学分析[J]. 基础医学与临床, 2024, 44(5): 630-636.
[11]	操辰新, 唐辉, 耿瑞璇, 郭伏平, 白春梅, 王颖轶, 李太生. 循环CD4⁺CD45RA⁺CD62L⁺ T细胞与接受EGFR-TKI治疗的转移性非小细胞肺癌预后相关[J]. 基础医学与临床, 2024, 44(5): 658-664.
[12]	傅晨, 李平. 重型再生障碍性贫血治疗的研究进展[J]. 基础医学与临床, 2024, 44(5): 719-723.
[13]	陈林木, 黄云秀. 壳寡糖上调SRBI核心岩藻糖基化修饰水平减弱小鼠动脉粥样硬化斑块形成[J]. 基础医学与临床, 2024, 44(4): 474-482.
[14]	王宇, 童安莉, 周玥, 张文倩, 崔云英, 景红丽, 李玉秀. ^99mTc-HYNIC-TOC显像和¹³¹I-MIBG显像在嗜铬细胞瘤和副神经节瘤中的诊断价值[J]. 基础医学与临床, 2024, 44(3): 374-378.
[15]	张忠文, 赵瑞, 张浩龙, 杨钰婷, 白金霞, 张浩令, 王薇. P2X7受体在癌痛中作用的研究进展[J]. 基础医学与临床, 2024, 44(3): 389-392.