不同细胞来源的外泌体在COPD中的研究进展

基础医学与临床 ›› 2020, Vol. 40 ›› Issue (12): 1721-1726.

不同细胞来源的外泌体在COPD中的研究进展

杨玥, 卞涛^*

南京医科大学附属无锡人民医院呼吸与危重症科, 江苏无锡 214000

收稿日期:2020-06-28 修回日期:2020-08-26 出版日期:2020-12-05 发布日期:2020-11-30
通讯作者: ^* biantaophd@126.com
基金资助:
江苏省干部保健科研课题(BJ17009);无锡市卫健委精准医疗(JZYX01)

Research progress of different cells derived exosomes in COPD

YANG Yue, BIAN Tao^*

Department of Respiratory and Critical Illness, Wuxi People's Hospital, Nanjing Medical University, Wuxi 214000, China

Received:2020-06-28 Revised:2020-08-26 Online:2020-12-05 Published:2020-11-30
Contact: ^* biantaophd@126.com

摘要/Abstract

摘要： 外泌体(exosomes)是一种几乎被所有类型的细胞分泌的脂质双分子层囊泡,其包裹各类蛋白质、DNA、mRNA、miRNA及LncRNA,是细胞之间沟通的重要媒介,参与机体各种生理、病理过程。在慢性阻塞性肺疾病(COPD)中,支气管上皮细胞、巨噬细胞和中性粒细胞等多种细胞均可通过分泌外泌体参与COPD气道重构与气肿的发生和发展,间充质干细胞和脂肪干细胞源外泌体则在COPD治疗中起到重要作用。

关键词: 外泌体, 慢性阻塞性肺疾病, 支气管上皮细胞, 巨噬细胞, 中性粒细胞

Abstract: Exosomes are lipid bilayer vesicles secreted by almost all types of cells, which consist of various proteins, DNA, mRNA, miRNA and LncRNA. They are an important medium for communication between cells and participate in various physiological and pathological processes. In chronic obstructive pulmonary disease (COPD), bronchial epithelial cells, macrophages, neutrophils and other cells can participate in COPD airway remodeling and emphysema by secreting exosomes. Moreover, mesenchymal stem cells and adipose stem cell-derived exosomes play an important role in the treatment of COPD.

Key words: exosomes, COPD, bronchial epithelial cell, macrophages, neutrophil

中图分类号:

杨玥, 卞涛. 不同细胞来源的外泌体在COPD中的研究进展[J]. 基础医学与临床, 2020, 40(12): 1721-1726.

YANG Yue, BIAN Tao. Research progress of different cells derived exosomes in COPD[J]. Basic & Clinical Medicine, 2020, 40(12): 1721-1726.

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