关键词: 肢端肥大症, 肿瘤, 流行病学, 发病机制, 胰岛素样生长因子1

Abstract: Neoplasms are well known to be a complication in cases of acromegaly, especially thyroid and colorectal neoplasia. The incidence and mortality of neoplastic complications in acromegaly patients are higher than that of the general population, the pathogenesis of which is correlated with elevated serum levels of insulin-like growth factor 1（IGF-1） and activation of IGF-1 signaling pathway. Early screening and intervention of neoplastic complications play an important role in decreasing the mortality of acromegaly patients.

Key words: acromegaly, neoplasm, epidemiology, pathogenesis, insulin-like growth factor 1