细胞焦亡在肾脏炎性反应中的作用研究进展

基础医学与临床 ›› 2017, Vol. 37 ›› Issue (10): 1470-1473.

细胞焦亡在肾脏炎性反应中的作用研究进展

吴燕升,高建东

上海曙光医院

收稿日期:2016-09-01 修回日期:2016-12-06 出版日期:2017-10-05 发布日期:2017-09-25
通讯作者: 高建东 E-mail:gaojiandong@hotmail.com

Advance in the study of pyroptosis in renal inflammatory injury

Received:2016-09-01 Revised:2016-12-06 Online:2017-10-05 Published:2017-09-25

摘要/Abstract

摘要： 细胞焦亡（pyroptoysis）是由活化的caspase-1触发的一种特殊的细胞程序性死亡。肾脏细胞焦亡在肾损伤中发挥着重要的作用。GSDMD切割焦亡关键蛋白caspase-1引起下游炎性反应因子IL-18，IL-1β的成熟和释放引起肾脏炎性反应和细胞焦亡发生。本文从NLRP3激活导致肾脏炎性反应、GSDMD裂解引发细胞焦亡等角度，阐释NLRP3-caspase-1—GSDMD介导的细胞焦亡在肾脏炎性反应中的作用。

关键词: 肾脏炎症，细胞焦亡，NLRP3，caspase-1，GSDMD

Abstract: Pyroptosis is activated caspase-1 trigger special programmed cell. Recent studies have confirmed the pyroptosis in renal cells plays an important role. GSDMD cleavage caspase-1 regulating the downstream inflammatory cytokines maturation、release and triggering inflammation and pyroptosis. From renal inflammatory injury from NLRP3 activation, pyroptosis from GSDMD breakage, the review try to explain the NLRP3－caspase-1-GSDMD drived pyroptosis in renal inflammation injury to explore the essence of kidney inflammatory damage.

Key words: kidney inflammation, pyroptosis, NLRP3，caspase-1, GSDMD

吴燕升高建东. 细胞焦亡在肾脏炎性反应中的作用研究进展[J]. 基础医学与临床, 2017, 37(10): 1470-1473.