基础医学与临床 ›› 2015, Vol. 35 ›› Issue (2): 257-261.

• 短篇综述 • 上一篇    下一篇

miR-126与血管的研究进展

李云1,宋银宏2,吕云波3   

  1. 1. 三峡大学附属人民医院
    2. 三峡大学医学院
    3. 三峡大学 人民医院 心内科
  • 收稿日期:2014-04-28 修回日期:2014-07-17 出版日期:2015-02-05 发布日期:2015-01-23
  • 通讯作者: 宋银宏 E-mail:490990106@qq.com

The research progress of miR - 126 and blood vessels

  • Received:2014-04-28 Revised:2014-07-17 Online:2015-02-05 Published:2015-01-23

摘要: MicroRNAs(MiRNAs)是一类高度保守的内源性非编码小分子单链RNA,它能通过非特异性识别靶基因mRNA,在翻译水平调节基因表达,从而调节细胞的多种生物功能。目前已发现多种miRNA,其中miR-126主要存在于血管内皮细胞及血小板中,与血管的生成、发育、修复功能密切相关,可以作为研究冠心病及其它血管性疾病的良好突破口。

关键词: miR-126, 血管, 血管内皮生长因子, 血管细胞粘附分子-1

Abstract: MicroRNAs (MiRNAs) is one kind of highly conservative endogenous non-coding single-stranded RNAs with small molecule, it is able to regulate gene expression at the translation level by non-specific identification of target genes’ mRNA, and it can regulate various biological functions of cells. Up to now a variety of microRNAs have been found, in which MiR-126 mainly exists in vascular endothelial cells and platelets, and is closely related to the generation, development and repairing of blood vessels. Therefore, MiR-126 will become a very good breach to study coronary heart disease and other vascular diseases.

Key words: miR-126, blood vessel, VEGF, VCAM-1