基础医学与临床 ›› 2014, Vol. 34 ›› Issue (10): 1434-1437.

• 短篇综述 • 上一篇    下一篇

ICOS/ICOSL的免疫调节作用与相关疾病的研究进展

李盛村,王婷,王国祥   

  1. 苏州大学
  • 收稿日期:2013-12-24 修回日期:2014-03-25 出版日期:2014-10-05 发布日期:2014-09-25
  • 通讯作者: 王国祥 E-mail:kwang63@163.com
  • 基金资助:
    苏州市科技计划应用基础研究项目

Research progress on immunomodulatory effects of ICOS/ICOSL and related diseases

  • Received:2013-12-24 Revised:2014-03-25 Online:2014-10-05 Published:2014-09-25

摘要: 协同刺激信号分子(ICOS)及其配体ICOSL在免疫应答和调节中起重要作用。研究发现ICOS结合ICOSL,与自身免疫性疾病和肿瘤有密切联系。靶向干预ICOS/ICOSL信号分子将可能为预防和治疗相关临床疾病提供新的途径。

关键词: ICOS/ICOSL, 免疫调节, 疾病

Abstract: Inducible co-stimulator(ICOS)and its ligand(ICOSL)play an important role in the response and regulation of immune system. It shows that ICOS bind to ICOSL relating to self-immune diseases and tumour. Targeted interventions of ICOS/ICOSL will provide new approaches for prevention and therapy of clinical diseases.

Key words: ICOS/ICOSL, immunomodulatory, diseases