基础医学与临床 ›› 2011, Vol. 31 ›› Issue (10): 1165-1167.

• 短篇综述 • 上一篇    下一篇

受体相互作用蛋白激酶RIP1在细胞信号转导途径中作用的研究进展

李莉1,闫言2   

  1. 1. 中国医学科学院 北京协和医院
    2. 北京协和医院
  • 收稿日期:2010-06-18 修回日期:2010-08-31 出版日期:2011-10-05 发布日期:2011-10-08
  • 通讯作者: 闫言 E-mail:yanyan20170@sina.com
  • 基金资助:
    2006年北京协和医院青年科研基金

Progress of study on functions of RIP1 in cell signal transduction

  • Received:2010-06-18 Revised:2010-08-31 Online:2011-10-05 Published:2011-10-08

摘要: 受体相互作用蛋白1是一类丝氨酸/苏氨酸蛋白激酶,是一种重要的细胞信号转导分子,从其被发现开始就成为了细胞信号转导的研究热点,但多集中在其在细胞凋亡中的作用,近年来的研究表明,受体相互作用蛋白1不仅参与了细胞的凋亡,还参与了细胞存活,细胞程序性坏死等多种信号的转导,是一类重要的调节细胞生存或死亡的信号分子,本文对受体相互作用蛋白1功能的研究进展做简要综述。

关键词: 受体相互作用蛋白1 , 肿瘤坏死因子 , 凋亡 , 程序性坏死

Abstract: Since the discovery of the first member ten years ago, the receptor-interacting protein (RIP) family kinases have emerged as essential sensors of cellular stress.The different members integrate both extracellular stress signals transmitted by various cell-surface receptors and signals emanating from intracellular stress. The cascades of events initiated by activated RIPs are complex. Not only are pro-survival, inflammatory and immune responses triggered by RIP kinases via the activation of transcription factors such as NF-κB and AP-1, but opposing, death-inducing programs can also be initiated by the RIP kinases. Hence, RIP kinases are crucial regulators of cell survival and cell death. This article summarizes the recent progress of RIP1 about its expression and function.

Key words: RIP1, TNF, Apoptosis, Necroptosis

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