基础医学与临床 ›› 2011, Vol. 31 ›› Issue (5): 574-577.

• 临床园地 • 上一篇    下一篇

原发性肺非霍奇金淋巴瘤的临床特点及预后分析

李剑,焦力,张薇,段明辉,邹农,周道斌,沈悌   

  1. 中国医学科学院 北京协和医学院 北京协和医院
  • 收稿日期:2011-02-16 修回日期:2011-03-08 出版日期:2011-05-05 发布日期:2011-05-06
  • 通讯作者: 焦力 E-mail:pumcjiaoli@hotmail.com

Clinical characteristics and outcome of primary pulmonary non-Hodgkin’s lymphoma

Jian LI1,Li JIAO1,Wei ZHANG2,Ming-hui DUAN1,Nong ZOU2,Dao-bin ZHOU2,Ti SHEN1   

  1. 1. PUMC Hospital, CAMS & PUMC
    2.
  • Received:2011-02-16 Revised:2011-03-08 Online:2011-05-05 Published:2011-05-06
  • Contact: Li JIAO E-mail:pumcjiaoli@hotmail.com

摘要: 目的 研究原发性肺非霍奇金淋巴瘤(PPL)的临床特征及预后。方法 回顾性分析北京协和医院确诊的30例PPL的临床表现、诊断手段、病理类型以及预后。结果 病例中,男性占46.7%,中位年龄为46岁。PPL患者没有特异的临床症状及影像学表现,甚至20%患者可无任何症状。中位发病至诊断时间为8个月,经支气管肺活检及经CT引导下肺活检的诊断率分别为33.3%和50%,而胸腔镜下肺活检及开胸肺活检的诊断率为100%。黏膜相关淋巴组织(MALT)淋巴瘤最为常见,占56.7%。在中位随诊39个月后,30例患者中有7例患者(23.3%)死亡。MALT组患者较非MALT组患者有着更低的IPI评分及更好的预后。结论 PPL是一种罕见的结外淋巴瘤,其诊断较为困难,非MALT类型的淋巴瘤患者预后较差。

关键词: 非霍奇金淋巴瘤, 肺, 原发性, 临床特征

Abstract: Objective To study the clinical characteristics and outcome of patients with primary pulmonary non-Hodgkin’s lymphoma (PPL). Methods The clinical features, diagnostic methods, pathological types and outcome of 30 patients with PPL diagnosed in PUMC Hospital were analyzed retrospectively. Results Of these 30 patients, 46.7% of patients were male and the median age was 46 years. These patients didn’t have specific clinical symptoms and radiological features and 20% patients were asymptomatic. The median time from onset to diagnosis of all patients was 8 months. The positive diagnostic rate of transbronchial lung biopsy, lung biopsy guided by computer tomography, and lung biopsy by thoracoscopy was 33.3%, 50% and 100%, respectively. The mucosa-associated lymphoid tissue (MALT) lymphoma was main type in PLL, which was found in 56.7% patients. 7 of 30 patients were dead after 39 months of median follow-up time. Compared with patients with non-MALT lymphoma, patients with MALT lymphoma had lower international prognostic index (IPI) score and better outcome. Conclusions The PPL is a rare extra-nodular lymphoma, which is difficult to diagnose. The patients with non-MALT lymphoma have better outcome in PPL.

Key words: non-Hodgkin’s lymphoma, lung, primary, clinical characteristics