SP1磷酸化在肿瘤发生发展中的作用

doi:10.16352/j.issn.1001-6325.2025.12.1657

基础医学与临床 ›› 2025, Vol. 45 ›› Issue (12): 1657-1661.doi: 10.16352/j.issn.1001-6325.2025.12.1657

SP1磷酸化在肿瘤发生发展中的作用

肖诚浦¹, 孙许涛², 宋运佳³, 解颖², 姜德友^2*

1.黑龙江中医药大学附属第一医院 2023级中医内科学,黑龙江哈尔滨 150040;
黑龙江中医药大学基础医学院 2.中医临床基础学科教研组; 3.药理教研组,黑龙江哈尔滨 150040

收稿日期:2024-12-30 修回日期:2025-04-28 出版日期:2025-12-05 发布日期:2025-11-25
通讯作者: ^*jiangdeyou@126.com
基金资助:
黑龙江省自然科学基金优秀青年项目(YQ2022H020);中国博士后科学基金会(2022M711089)

Role of SP1 phosphorylation in development of tumor

XIAO Chengpu¹, SUN Xutao², SONG Yunjia³, XIE Ying², JIANG Deyou^2*

1. Internal Medicine of Traditional Chinese Medicine, Grade 2023, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040;
2. Clinical Foundation of Chinese Medicine Teaching and Research Group; 3. Pharmacology Teaching and Research Group, School of Basic Medicine, Heilongjiang University of Chinese Medicine, Harbin 150040, China

Received:2024-12-30 Revised:2025-04-28 Online:2025-12-05 Published:2025-11-25
Contact: ^*jiangdeyou@126.com

摘要/Abstract

摘要： 磷酸化是特异性蛋白1(SP1) 常见的翻译后修饰,能通过改变SP1结构影响其转录活性和DNA结合稳定性。SP1的磷酸化能促进癌细胞的端粒维持、免疫逃逸、血管内皮生长因子生成等,推动肿瘤的侵袭、转移,增加化疗药物耐药性。

关键词: 特异性蛋白1, 磷酸化修饰, 蛋白激酶

Abstract: Phosphorylation is a common post-translational modification of specific protein 1(SP1), which can affect its transcriptional activity and DNA-binding stability by altering the structure of SP1. Phosphorylation of SP1 can promote telomere maintenance, immune escape, and production of vascular endothelial growth factor in cancer cells, promote tumor invasion and metastasis, and increase drug resistance to chemotherapy.

Key words: specificity protein 1, phosphorylation, protein kinase

中图分类号:

R966

肖诚浦, 孙许涛, 宋运佳, 解颖, 姜德友. SP1磷酸化在肿瘤发生发展中的作用[J]. 基础医学与临床, 2025, 45(12): 1657-1661.

XIAO Chengpu, SUN Xutao, SONG Yunjia, XIE Ying, JIANG Deyou. Role of SP1 phosphorylation in development of tumor[J]. Basic & Clinical Medicine, 2025, 45(12): 1657-1661.

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SP1磷酸化在肿瘤发生发展中的作用

Role of SP1 phosphorylation in development of tumor

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