铁死亡在蛛网膜下腔出血早期脑损伤发病机制中作用的研究进展

doi:10.16352/j.issn.1001-6325.2023.03.486

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (3): 486-489.doi: 10.16352/j.issn.1001-6325.2023.03.486

铁死亡在蛛网膜下腔出血早期脑损伤发病机制中作用的研究进展

曲大鹏¹, 孙会艳², 李强^3*, 王洪权⁴

赤峰学院附属医院 1.急诊科;
3.神经内科, 内蒙古自治区赤峰 024005;
2 赤峰学院医学部, 内蒙古自治区赤峰 024000;
4.航天中心医院/北京大学航天临床医学院神经内科,北京 100049

收稿日期:2022-06-28 修回日期:2022-11-30 出版日期:2023-03-05 发布日期:2023-02-27
通讯作者: * liqiang1980_1981@126.com
基金资助:
国家自然科学基金(81260196);内蒙古自然科学基金(2020MS08175, 2021MS08131, 2021LHMS08024); 内蒙古自治区高校科研项目(NJZY19218); 航天中心医院院级基金(YN202104)

Recent progress of the role of ferroptosis in the pathogenesis of early brain injury after subarachnoid hemorrhage

QU Dapeng¹, SUN Huiyan², LI Qiang^3*, WANG Hongquan⁴

1. Department of Emergency Medicine;
3. Department of Neurology, the Affiliated Hospital of Chifeng University, Chifeng 024005;
2. Health Science Center, Chifeng University, Chifeng 024000;
4. Department of Neurology, Aerospace Center Hospital, Aerospace School of Clinical Medicine, Peking University, Beijing 100049,China

Received:2022-06-28 Revised:2022-11-30 Online:2023-03-05 Published:2023-02-27
Contact: * liqiang1980_1981@126.com

摘要/Abstract

摘要： 蛛网膜下腔出血(SAH) 导致铁死亡,表现为铁代谢失调、脂质过氧化增加和谷胱甘肽/谷胱甘肽过氧化物酶4(GSH/GPX4)的抑制。铁死亡介导SAH后72小时内早期脑损伤(EBI-SAH)进而导致SAH预后不良。通过药物靶向抑制铁死亡能够减轻EBI-SAH,为未来治疗EBI-SAH提供了新的靶点。

关键词: 蛛网膜下腔出血, 早期脑损伤, 铁死亡, 铁死亡抑制剂

Abstract: Subarachnoid hemorrhage (SAH) leads to ferroptosis with clinical evidence like iron metabolism deregulation, increased lipid peroxitation(LPO) and the inhibition of glutathione/glutathione peroxides 4(GSH/GPX4). Ferroptosis mediated early brain injury (EBI) may occur in the 72-hour period following SAH (EBI-SAH) leads to the poor prognosis of SAH. Pharmacological targeting at ferroptosis mitigate EBI-SAH, provides a new target for future treatment and prevention of EBI-SAH through targeting at ferroptosis.

Key words: subarachnoid hemorrhage, early brain injury, ferroptosis, ferroptosis inhibitor

中图分类号:

R743.3

曲大鹏, 孙会艳, 李强, 王洪权. 铁死亡在蛛网膜下腔出血早期脑损伤发病机制中作用的研究进展[J]. 基础医学与临床, 2023, 43(3): 486-489.

QU Dapeng, SUN Huiyan, LI Qiang, WANG Hongquan. Recent progress of the role of ferroptosis in the pathogenesis of early brain injury after subarachnoid hemorrhage[J]. Basic & Clinical Medicine, 2023, 43(3): 486-489.

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铁死亡在蛛网膜下腔出血早期脑损伤发病机制中作用的研究进展

Recent progress of the role of ferroptosis in the pathogenesis of early brain injury after subarachnoid hemorrhage

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