中性粒细胞胞外诱捕网在肺部疾病中作用的研究进展

doi:10.16352/j.issn.1001-6325.2023.03.481

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (3): 481-485.doi: 10.16352/j.issn.1001-6325.2023.03.481

中性粒细胞胞外诱捕网在肺部疾病中作用的研究进展

丁雨, 吴艳, 卞涛^*

南京医科大学附属无锡人民医院呼吸与危重症科,江苏无锡 214023

收稿日期:2022-01-10 修回日期:2022-05-30 出版日期:2023-03-05 发布日期:2023-02-27
通讯作者: * biantaophd@126.com
基金资助:
国家自然科学基金(82173472)

Research progress on the role of neutrophil extracellular traps in lung diseases

DING Yu, WU Yan, BIAN Tao^*

Department of Respiratory and Critical Care Medicine, Wuxi People's Hospital Affiliated to Nanjing Medical University,Wuxi 214023,China

Received:2022-01-10 Revised:2022-05-30 Online:2023-03-05 Published:2023-02-27
Contact: * biantaophd@126.com

摘要/Abstract

摘要： 中性粒细胞是肺部的常驻免疫细胞,受到刺激后,可释放含有中性粒细胞弹性蛋白酶、髓过氧化物酶、瓜氨酸组蛋白、细胞骨架蛋白的解凝染色质,即中性粒细胞胞外诱捕网(NETs)。NETs在肺部疾病中发挥抗感染作用,但过量的NETs释放也会导致肺部组织损伤、炎性反应增强和促进肿瘤转移。本文简要总结NETs的相关研究进展,为研发治疗肺部疾病的潜在药物提供新的思路。

关键词: 中性粒细胞胞外诱捕网, 肺部疾病

Abstract: Neutrophils are resident immune cells in the lung, which can release decondensed chromatin containing neutrophil elastases, myeloperoxidases, citrullinated histones and cytoskeletal proteins upon stimulation, namely neutrophil extracellular traps(NETs). NETs play an anti-infective role in lung diseases. But excessive NETs release potentially leads to cause lung tissue injury, enhances inflammatory response and promotes tumor metastasis. These results of research provide some new ideas for the development of potential drugs.

Key words: neutrophil extracellular traps, lung disease

中图分类号:

丁雨, 吴艳, 卞涛. 中性粒细胞胞外诱捕网在肺部疾病中作用的研究进展[J]. 基础医学与临床, 2023, 43(3): 481-485.

DING Yu, WU Yan, BIAN Tao. Research progress on the role of neutrophil extracellular traps in lung diseases[J]. Basic & Clinical Medicine, 2023, 43(3): 481-485.

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中性粒细胞胞外诱捕网在肺部疾病中作用的研究进展

Research progress on the role of neutrophil extracellular traps in lung diseases

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