中性粒细胞及NETs在骨与软组织肉瘤中的作用

doi:10.16352/j.issn.1001-6325.2024.10.1442

基础医学与临床 ›› 2024, Vol. 44 ›› Issue (10): 1442-1446.doi: 10.16352/j.issn.1001-6325.2024.10.1442

中性粒细胞及NETs在骨与软组织肉瘤中的作用

张钦荣, 刘春霞^*

广州医科大学附属第二医院病理科,广东广州 510260

收稿日期:2024-01-04 修回日期:2024-04-01 出版日期:2024-10-05 发布日期:2024-09-27
通讯作者: ^* liuliu2239@126.com
基金资助:
国家自然科学基金(81960485); 广州市科技计划市校联项目(202201020104)

Role of neutrophils and NETs in osteosarcoma and soft tissue sarcoma

ZHANG Qinrong, LIU Chunxia^*

Department of Pathology, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China

Received:2024-01-04 Revised:2024-04-01 Online:2024-10-05 Published:2024-09-27
Contact: ^* liuliu2239@126.com

摘要/Abstract

摘要： 中性粒细胞是肿瘤微环境的重要成分之一。中性粒细胞胞外诱捕网(NETs)是中性粒细胞释放的网状结构,其形成过程被称为中性粒细胞炎性凋亡(NETosis)。肿瘤微环境中的中性粒细胞即肿瘤相关中性粒细胞(TANs),包括N1和N2两种表型,对肿瘤具有双向调控作用。其中N1型抑制肿瘤生长,N2型促进肿瘤生长,N1型与N2型受肿瘤微环境影响会发生相互转化。中性粒细胞及NETs在骨与软组织肉瘤中也发挥重要作用,可以影响肿瘤进展并能预测患者预后,阻断NETs形成可能是潜在的治疗靶点。

关键词: 骨肉瘤, 软组织肉瘤, 中性粒细胞, 中性粒细胞胞外诱捕网, 肿瘤相关中性粒细胞

Abstract: Neutrophils are one of the important components of the tumor microenvironment. Neutrophil extra cellular traps (NETs) are a network structure released by neutrophils, and their formation process is called neutrophil inflammatory apoptosis (NETosis). Neutrophils in the tumor microenvironment, also known as tumor associated neutrophils (TANs). TANs including N1 phenotype and N2 phenotype have a bidirectional regulatory effect on tumors. While N1 phenotype inhibits tumor growth, and N2 phenotype promotes tumor growth, and N1 and N2 types undergo mutual transformation due to the influence of the tumor microenvironment. Neutrophils and NETs also play important roles in bone and osteosarcoma tissue sarcoma, which can affect tumor progression and predict patient prognosis. Blocking the formation of NETs may be a potential therapeutic target.

Key words: osteosarcoma, soft tissue sarcoma, neutrophil, neutrophil extracellular traps, tumor-associated neutrophils

中图分类号:

R738.6

张钦荣, 刘春霞. 中性粒细胞及NETs在骨与软组织肉瘤中的作用[J]. 基础医学与临床, 2024, 44(10): 1442-1446.

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中性粒细胞及NETs在骨与软组织肉瘤中的作用

Role of neutrophils and NETs in osteosarcoma and soft tissue sarcoma

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