TERT调控线粒体氧化应激在疾病中的作用

doi:10.16352/j.issn.1001-6325.2024.10.1436

基础医学与临床 ›› 2024, Vol. 44 ›› Issue (10): 1436-1441.doi: 10.16352/j.issn.1001-6325.2024.10.1436

TERT调控线粒体氧化应激在疾病中的作用

田宗源, 李展, 刘瑞霞^*

首都医科大学附属北京妇产医院/北京妇幼保健院中心实验室, 北京 100026

收稿日期:2024-01-04 修回日期:2024-04-01 出版日期:2024-10-05 发布日期:2024-09-27
通讯作者: ^* liuruixia@ccmu.edu.cn
基金资助:
国家自然科学基金(81871605)

Role of TERT in regulating mitochondrial oxidative stress in diseases

TIAN Zongyuan, LI Zhan, LIU Ruixia^*

Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China

Received:2024-01-04 Revised:2024-04-01 Online:2024-10-05 Published:2024-09-27
Contact: ^* liuruixia@ccmu.edu.cn

摘要/Abstract

摘要： 氧化应激是活性氧(ROS)形成与抗氧化剂水平不平衡的结果,线粒体是调控氧化应激的重要细胞器,端粒酶反转录酶(TERT)不仅存在于细胞核维持端粒酶的活性和端粒长度,还可逆地转位到线粒体,提高线粒体氧化呼吸链活性,减少线粒体活性氧(mtROS)的产生、激活GSH系统和自噬通路,促进mtROS的清除,从而下调mtROS水平,减轻氧化应激及其损伤,维持细胞氧化还原平衡和机体的正常功能。

关键词: 端粒酶反转录酶(TERT), 氧化应激, 活性氧, 铁死亡, 自噬

Abstract: Oxidative stress is the result of imbalance between the formation of reactive oxygen species (ROS) and antioxidant level. Mitochondria are important organelles regulating oxidative stress. Telomerase reverse transcriptase (TERT) not only in the nucleus to maintain telomerase activity and telomere length, but also reversibly transits to mitochondria. Improving the activity of oxidative respiratory chain of mitochondria to reduce the production of mitochondrial reactive oxygen species (mtROS) and to activate GSH system as well as autophagy pathway to promote the clearance of mtROS are all important to down-regulate the level of mtROS, which will alleviate oxidative stress and damage and keep the REDOX balance of cells and the normal function of the body.

Key words: telomerase reverse transcriptase(TERT), oxidative stress, reactive oxygen species, ferroptosis, autophagy

中图分类号:

田宗源, 李展, 刘瑞霞. TERT调控线粒体氧化应激在疾病中的作用[J]. 基础医学与临床, 2024, 44(10): 1436-1441.

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TERT调控线粒体氧化应激在疾病中的作用

Role of TERT in regulating mitochondrial oxidative stress in diseases

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