肺泡巨噬细胞诱导免疫应答对肺组织炎性损伤作用机制的研究进展

doi:10.16352/j.issn.1001-6325.2023.10.1585

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (10): 1585-1589.doi: 10.16352/j.issn.1001-6325.2023.10.1585

肺泡巨噬细胞诱导免疫应答对肺组织炎性损伤作用机制的研究进展

张晨, 蒲翔^*, 苏进, 唐依莲, 曾宪法

贵州中医药大学基础医学院,贵州贵阳 550025

收稿日期:2023-03-31 修回日期:2023-07-24 出版日期:2023-10-05 发布日期:2023-10-05
通讯作者: *314745595@qq.com
基金资助:
国家自然科学基金(82060913)

Advances in the mechanism of alveolar macrophage-induced immune response to inflammation injury of lung tissue

ZHANG Chen, PU Xiang^*, SU Jin, TANG Yilian, ZENG Xianfa

School of Basic Medicine,Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China

Received:2023-03-31 Revised:2023-07-24 Online:2023-10-05 Published:2023-10-05
Contact: *314745595@qq.com

摘要/Abstract

摘要： 肺泡巨噬细胞作为专职性抗原提呈细胞,在宿主免疫防御及适应性免疫应答中发挥重要作用。病原体在肺组织定植引起局部感染后,肺泡巨噬细胞可通过其表面的模式识别受体识别并吞噬病原体,严重者可进一步活化,将摄取的抗原物质提呈给适应性免疫细胞,并可根据组织微环境的变化,转化为促炎或抗炎表型,通过释放相关信号因子,促使机体产生一系列免疫应答,诱导肺部炎性损伤及组织的修复。

关键词: 细菌性肺炎, 肺泡巨噬细胞, 炎性损伤, 免疫应答

Abstract: As specialized antigen-presenting cells, alveolar macrophages play an important role in host immune defense and adaptive immune response. After local infection caused by pathogens which colonize lung tissue, alveolar macrophages can recognize and engulf pathogens through pattern recognition receptors on their surface. In severe cases, the marophages may be further activated to present the ingested antigenic material to adaptive immune cells, and can be converted into a pro-inflammatory or anti-inflammatory phenotype depending on changes in the tissue microenvironment.By releasing relevant signaling factors, immune responses could regulate lung inflammation injury and tissue repair.

Key words: bacterial pneumonia, alveolar macrophages, inflammatory injury, immune response

中图分类号:

R392.9

张晨, 蒲翔, 苏进, 唐依莲, 曾宪法. 肺泡巨噬细胞诱导免疫应答对肺组织炎性损伤作用机制的研究进展[J]. 基础医学与临床, 2023, 43(10): 1585-1589.

ZHANG Chen, PU Xiang, SU Jin, TANG Yilian, ZENG Xianfa. Advances in the mechanism of alveolar macrophage-induced immune response to inflammation injury of lung tissue[J]. Basic & Clinical Medicine, 2023, 43(10): 1585-1589.

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肺泡巨噬细胞诱导免疫应答对肺组织炎性损伤作用机制的研究进展

Advances in the mechanism of alveolar macrophage-induced immune response to inflammation injury of lung tissue

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