基础医学与临床 ›› 2017, Vol. 37 ›› Issue (12): 1761-1764.

• 短篇综述 • 上一篇    下一篇

外排体在脑胶质瘤中的研究进展

王子豪1,高路1,郭晓鹏1,幸兵2   

  1. 1. 中国医学科学院 北京协和医学院 北京协和医院
    2. 北京协和医院
  • 收稿日期:2016-09-28 修回日期:2017-01-17 出版日期:2017-12-05 发布日期:2017-11-29
  • 通讯作者: 幸兵 E-mail:xingbingemail@aliyun.com

Research progresses on exosomes in glioma

Zi-Hao WANG1, Xiao-peng GUO3,兵 幸   

  • Received:2016-09-28 Revised:2017-01-17 Online:2017-12-05 Published:2017-11-29
  • Contact: 兵 幸 E-mail:xingbingemail@aliyun.com

摘要: 外排体是细胞分泌到细胞外基质中的一种功能性囊泡,胶质瘤外排体在胶质瘤的发生发展、辅助诊断和治疗中的作用日益受到重视。本文对常见胶质瘤外排体标记物,介导免疫治疗、抗肿瘤治疗载体、干预肿瘤细胞信号通路等方面进行总结。

关键词: 脑肿瘤, 外排体, 生物标志物, 液相活检

Abstract: Exosome is a kind of functional vesicles secreted to the extracellular matrix. The role of glioma exosomes in the development, diagnosis and treatment of glioma is increasingly recognized. This review aims to summarize the most common biomarkers of glioma exosomes and the applications of exosomes in treatments, which mainly includes mediating immune therapy, anti-tumor therapeutic vehicles, and intervention of intercellular communications between tumor cells.

Key words: glioma, exosomes, biomarkers, liquid biopsy

中图分类号: