基础医学与临床 ›› 2017, Vol. 37 ›› Issue (12): 1765-1769.

• 短篇综述 • 上一篇    下一篇

Sox5与肿瘤的相关性研究进展

宋国栋,牛远杰   

  1. 天津医科大学第二医院
  • 收稿日期:2016-12-05 修回日期:2017-01-17 出版日期:2017-12-05 发布日期:2017-11-29
  • 通讯作者: 牛远杰 E-mail:venussoon1982@aliyun.com

Research progress of the correlation of Sox5 and tumor

  • Received:2016-12-05 Revised:2017-01-17 Online:2017-12-05 Published:2017-11-29

摘要: Sox5定位于12p12.1,共包含29个外显子,可转录出5个异构体,其中L-SOX5A相对研究较多,其功能众多,如调节着胚胎发育、决定着细胞分化,还参与多种肿瘤的发生,如淋巴瘤、乳腺癌、胶质瘤和前列腺癌等。

关键词: Sox家族, Sox5, 细胞分化, 肿瘤转移

Abstract: Sox5 gene is located on 12p12.1, containing 29 exons, it can transcript 5 variants, thus produce 5 isoforms. L-SOX5A is an isoform relative extensive studied, its functions include regulate embryonic development, and determine cell differentiation. Sox5 was implicated in prostate cancer, breast cancer and lymphoma.

Key words: Sox family, Sox5, cell differentiation, tumor metastasis