Chinese Journal of Contemporary Neurology and Neurosurgery ›› 2019, Vol. 19 ›› Issue (12): 954-957. doi: 10.3969/j.issn.1672-6731.2019.12.008

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Predictive value of preoperative MRI enhancement features on postoperative recurrent time in recurrent glioblastoma patients

SONG Kun1, QIN Zhi-yong1, XU Hao1, QIU Tian-ming1, CHENG Ai-lan2, CHU Shu-guang2   

  1. 1. epartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China;
    2. Department of Radiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China                      SONG Kun and QIN Zhi-yong contributed equally to the article
  • Received:2019-12-19 Online:2019-12-25 Published:2020-01-03
  • Contact: CHU Shu-guang (Email:chushu1018@hotmail.com)

复发胶质母细胞瘤患者术前MRI强化特征对术后复发时间的预测价值

宋昆1, 秦智勇1, 徐浩1, 邱天明1, 程爱兰2, 初曙光2   

  1. 1. 200040 上海, 复旦大学附属华山医院神经外科;
    2. 200120 上海, 同济大学附属东方医院医学影像科
  • 通讯作者: 初曙光,Email:chushu1018@hotmail.com

Abstract:

Objective To analyze the relationship between preoperative enhanced MRI manifestation and recurrent time of recurrent glioblastoma, and to explore the predictive value of imaging signs for recurrence time. Methods A total of 36 patients with pathologically confirmed glioblastoma were collected from February 2012 to April 2017. All patients underwent preoperative and postoperative T1WI and enhanced MRI scans, and enhanced cross-sections and sagittal or coronary scans were performed. Manually measure the volume of the lesion-enhanced and non-enhanced necrotic areas on the enhanced MRI image. The totality was divided into 2 groups according to the percentage of necrosis that accounts for the entire tumor volume. Necrosis in group A accounts for > 50% of the total tumor volume, and necrosis in group B accounts for < 50% of the total tumor volume. Analyze the enhanced MRI features before surgery, the time of first recurrence, MRI manifestations and overall survival (OS). Results The recurrence time in group A was significantly shorter than that in group B[(6.00 ±0.99) months vs. (9.00 ±1.49) months, P=0.049]. Necrotic-based glioblastomas recurred faster. When stratifying patients in group A and group B based on clinical characteristics, the recurrence time of patients in group A was still significantly shorter than that in group B in the group of age < 65 years old and receiving radiotherapy and chemotherapy[6 (3, 8) months vs. 9 (6, 13) months, 6 (6, 10) months vs. 12 (3, 24) months; P<0.05, for all]. Conclusions Preoperative enhanced MRI findings have predictive value for postoperative recurrence in patients with glioblastoma who are younger than 65 years old and receive radiotherapy and chemotherapy.

Key words: Glioblastoma, Recurrence, Magnetic resonance imaging

摘要:

目的 分析胶质母细胞瘤患者术前MRI强化特征与术后复发时间的关系,探讨影像学征象对术后复发时间的预测价值。方法 收集2012年2月至2017年4月经组织病理证实的36例胶质母细胞瘤患者手术前后T1WI平扫和增强扫描资料,手动测量增强MRI图像上病灶强化区和无强化坏死区体积,根据坏死区所占整个瘤体体积百分比进行结构测量(A组坏死区所占比例 > 50%,B组实性区所占比例 > 50%),分析两组患者术前MRI强化特征、术后首次复发时间、MRI表现及总生存期的特点。结果 A组患者术后复发时间短于B组患者[(6.00 ±0.99)个月对(9.00 ±1.49)个月,P=0.049],以坏死类型为主的胶质母细胞瘤患者术后复发时间更早。基于临床特征对A组和B组患者进行分层,在年龄<65岁、接受放化疗分层中,A组患者复发时间仍短于B组患者[6(3,8)个月对9(6,13)个月、6(6,10)个月对12(3,24)个月,均P<0.05]。结论 术前增强MRI病灶类型和表现,对年龄 < 65岁、接受放化疗的胶质母细胞瘤患者的术后复发时间具有预测价值。

关键词: 胶质母细胞瘤, 复发, 磁共振成像