Chinese Journal of Contemporary Neurology and Neurosurgery ›› 2018, Vol. 18 ›› Issue (10): 705-708. doi: 10.3969/j.issn.1672-6731.2018.10.002

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Progress of dorsal root ganglia in mechanism of pain

LIU Jing-zhi   

  1. Pain Management Center, the Second Hospital of Tianjin Medical University, Tianjin 300211, China
  • Online:2018-10-25 Published:2018-11-26
  • Contact: LIU Jing-zhi(Email: ljz77618@126.com)
  • Supported by:

    This study was supported by the National Natural Science Foundation for Young Scientists of China (No. 51303133) and Tianjin Application Foundation and Advanced Technology Research Project (No. 09JCYBJC13200).

背根神经节参与疼痛机制研究进展

刘靖芷   

  1. 300211 天津医科大学第二医院疼痛治疗中心
  • 通讯作者: 刘靖芷(Email: ljz77618@126.com)
  • 基金资助:

    国家自然科学基金青年科学基金资助项目(项目编号:51303133);天津市应用基础及前沿技术研究计划项目(项目编号:09JCYBJC13200)

Abstract:

Dorsal root ganglia (DRG) neurons are the primary afferent neurons of algaesthesis of trunk and extremities. DRG transmits and accommodates sensations and accepts and conveys nociception, so it plays an important role in the mechanism of pain. DRG is accessible to clinical interventions for the control of intractable pain and is a target for neuromodulation therapy. This review focuses on sodium ion channels in DRG, glial cells and inflammatory reaction which are mainly involved in the mechanism of pain.

Key words: Ganglia, spinal, Pain, Review

摘要:

背根神经节神经元是躯干、四肢痛觉的初级传入神经元,具有传输和调节机体感觉、接受和传导伤害性感受的功能,在疼痛机制中发挥重要作用。临床以背根神经节为靶点的介入治疗和神经调节治疗可以缓解疼痛。本文拟就背根神经节的钠离子通道、胶质细胞和炎症反应在疼痛机制中的研究进展进行综述。

关键词: 神经节, 脊, 疼痛, 综述