Chinese Journal of Contemporary Neurology and Neurosurgery ›› 2015, Vol. 15 ›› Issue (2): 165-168. doi: 10.3969/j.issn.1672-6731.2015.02.016

Previous Articles     Next Articles

Research progress of role of bacteria and their metabolites in neurological diseases

FENG Xin-wei, ZHANG Ge   

  1. Department of Microbial and Biochemical Pharmacy, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510275, Guangdong, China
  • Online:2015-02-25 Published:2015-02-24
  • Contact: ZHANG Ge (Email: zhangge@mail.sysu.edu.cn)
  • Supported by:

    This study was supported by National Natural Science Foundation of China (No. 81372573).

细菌及其代谢产物在神经系统疾病作用的研究进展

冯新为, 张革   

  1. 510275 广州,中山大学药学院微生物与生化药学实验室
  • 通讯作者: 张革 (Email:zhangge@mail.sysu.edu.cn)
  • 基金资助:

    国家自然科学基金资助项目(项目编号:81372573)

Abstract: Mycobacteria and their metabolites which participate in the reprogramming of neurogliocytes and neuroprotection were summarized in this article, and the probable signaling pathways were also analyzed. The bacteria from digestive tract including periodontal and intestines involving in central nervous system diseases, such was Alzhermer's disease (AD), multiple sclerosis (MS), autism and so on, was introduced as well.

Key words: Nervous system diseases, Mycobacterium, Bacteria, Intestines, Review

摘要: 对分枝杆菌属细菌及其代谢产物参与神经胶质细胞重编程和神经保护过程进行阐述,并分析其中可能涉及的信号转导通路;系统介绍包括牙周病相关细菌、肠道菌群在内的消化道细菌及其代谢产物与阿尔茨海默病、多发性硬化、自闭症等中枢神经系统疾病发生与发展的关系。

关键词: 神经系统疾病, 分枝杆菌属, 细菌, 肠, 综述