Abstract: The clinical manifestations, cerebrospinal fluid (CSF), imaging and EEG characteristics of 10 patients with epilepsy secondary to fungal meningitis were retrospectively analyzed, so as to improve the diagnosis and treatment of fungal meningitis. The results suggest that patients with fungal meningitis involving the cortex were sensitive to secondary epilepsy; imaging examinations showing frontotemporal lesions and EEG showing moderate-to-severe abnormalities were sensitive to secondary epilepsy. Whether the increasing of endotoxin and (1-3)-β-D-dextran in CSF of patients with fungal meningitis is associated with secondary epilepsy needs further research.

Key words: Meningitis, fungal, Epilepsy, Cerebrospinal fluid, Magnetic resonance imaging, Electroencephalography

摘要： 对10 例真菌性脑膜炎继发癫痫患者的临床表现，以及脑脊液、影像学和脑电图特点进行回顾分析，提示真菌性脑膜炎累及大脑皮质者易继发癫痫，尤其是影像学检查发现额颞叶病灶、脑电图呈中至重度异常的患者更易诱发癫癫痫发作。真菌性脑膜炎患者脑脊液内毒素和（1-3）-β-D 葡聚糖水平均升高，是否与继发癫痫相关尚待进一步观察。

关键词: 脑膜炎, 真菌性, 癫痫, 脑脊髓液, 磁共振成像, 脑电描记术