Chinese Journal of Contemporary Neurology and Neurosurgery ›› 2013, Vol. 13 ›› Issue (4): 334-337. doi: 10.3969/j.issn.1672-6731.2013.04.016

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Imaging and clinical characteristics of sporadic Creutzfeldt-Jakob disease

GAO Yan, ZHANG Wei, FENG Juan, HAN Shun-chang   

  1. Department of Neurology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, China
  • Online:2013-04-25 Published:2013-05-01
  • Contact: FENG Juan (Email: fengjuan99@hotmail.com)

散发型克-雅病影像学特点与临床症状分析

高岩, 张威, 冯娟, 韩顺昌   

  1. 110004 沈阳,中国医科大学附属盛京医院第一神经内科
  • 通讯作者: 冯娟 (Email:fengjuan99@hotmail.com )

Abstract: Five patients with sporadic Creutzfeldt-Jakob disease (sCJD) presented rapidly progressive dementia which were subacute onset from 1 to 4 months. Among these cases, periodic synchronous discharge (PSD) of electroencephalography (EEG) was seen in 2 patients. Besides, 4 patients obtained positive results in cerebrospinal fluid (CSF) analysis for 14-3-3 protein. The cranial MRI examination showed symmetrical or asymmetrical colored-ribbon-shaped high signals in cerebral cortex or basal ganglia by diffusion weighted imaging (DWI), suggesting that DWI had high sensitivity and specificity for the diagnosis of sCJD as a preferred method in the clinical examination of sCJD.

Key words: Creutzfeldt-Jakob syndrome, Diffusion magnetic resonance imaging

摘要: 散发型克-雅病患者共计5 例,临床主要表现为快速进展性痴呆,发病时间 1 ~ 4 个月。其中2 例脑电图呈现特征性周期性同步放电,4 例脑脊液14-3-3 蛋白检测阳性。MRI 扩散加权成像均显示皮质或基底节对称性或非对称性“彩带”样高信号,提示扩散加权成像对克? 雅病的诊断敏感且具有特异性,可作为临床首选检查方法。

关键词: 克-亚综合征, 磁共振成像, 弥散