| 1 |
Rong S , Xu G , Liu B , Sun Y , Snetselaar LG , Wallace RB , Li B , Liao J , Bao W . Trends in mortality from Parkinson disease in the United States, 1999-2019. Neurology, 2021, 97: e1986- e1993.
|
| 2 |
Simon DK , Tanner CM , Brundin P . Parkinson disease epidemiology, pathology, genetics, and pathophysiology. Clin Geriatr Med, 2020, 36: 1- 12.
doi: 10.1016/j.cger.2019.08.002
|
| 3 |
Wu Z , Bagarolo GI , Thoröe-Boveleth S , Jankowski J . "Lipidomics": mass spectrometric and chemometric analyses of lipids. Adv Drug Deliv Rev, 2020, 159: 294- 307.
doi: 10.1016/j.addr.2020.06.009
|
| 4 |
Song S , Luo Z , Li C , Huang X , Shiroma EJ , Simonsick EM , Chen H . Changes in body composition before and after Parkinson's disease diagnosis. Mov Disord, 2021, 36: 1617- 1623.
doi: 10.1002/mds.28536
|
| 5 |
Kim R , Choi S , Byun K , Kang N , Suh YJ , Jun JS , Jeon B . Association of early weight change with cognitive decline in patients with Parkinson disease. Neurology, 2023, 100: e232- e241.
doi: 10.1212/WNL.0000000000201826
|
| 6 |
Yoon SY , Heo SJ , Lee HJ , Shin J , Kim YW , Yang SN , Park YG . Initial BMI and weight loss over time predict mortality in Parkinson disease. J Am Med Dir Assoc, 2022, 23: 1719.e1- 1719.e7.
doi: 10.1016/j.jamda.2022.07.015
|
| 7 |
Urso D , van Wamelen DJ , Batzu L , Leta V , Staunton J , Pineda-Pardo JA , Logroscino G , Sharma J , Ray Chaudhuri K . Clinical trajectories and biomarkers for weight variability in early Parkinson's disease. NPJ Parkinsons Dis, 2022, 8: 95.
doi: 10.1038/s41531-022-00362-3
|
| 8 |
Hasuike Y , Endo T , Koroyasu M , Matsui M , Mori C , Yamadera M , Fujimura H , Sakoda S . Bile acid abnormality induced by intestinal dysbiosis might explain lipid metabolism in Parkinson's disease. Med Hypotheses, 2020, 134: 109436.
doi: 10.1016/j.mehy.2019.109436
|
| 9 |
Lv Y , Xu B , Zhang X , Chen C , Gao Y , Li N . Association of serum cholesterol with Parkinson's disease in a cohort of statin-free individuals. Brain Behav, 2022, 12: e2454.
doi: 10.1002/brb3.2454
|
| 10 |
Guo X , Song W , Chen K , Chen X , Zheng Z , Cao B , Huang R , Zhao B , Wu Y , Shang HF . The serum lipid profile of Parkinson's disease patients: a study from China. Int J Neurosci, 2015, 125: 838- 844.
doi: 10.3109/00207454.2014.979288
|
| 11 |
Hong X , Guo W , Li S . Lower blood lipid level is associated with the occurrence of Parkinson's disease: a Meta-analysis and systematic review. Int J Clin Pract, 2022, ID9773038.
|
| 12 |
Li Y , Ji G , Lian M , Liu X , Xu Y , Gui Y . Effect of PLA2G6 and SMPD1 variants on the lipid metabolism in the cerebrospinal fluid of patients with Parkinson's disease: a non-targeted lipidomics study. Neurol Ther, 2023, 12: 2021- 2040.
doi: 10.1007/s40120-023-00542-0
|
| 13 |
Pingale TD , Gupta GL . Novel therapeutic approaches for Parkinson's disease by targeting brain cholesterol homeostasis. J Pharm Pharmacol, 2021, 73: 862- 873.
doi: 10.1093/jpp/rgaa063
|
| 14 |
Kiani L . 27-Hydroxycholesterol propagates α-synuclein pathology in Parkinson disease. Nat Rev Neurol, 2023, 19: 573.
|
| 15 |
Di Natale C , Monaco A , Pedone C , Tessitore A , De Mase A , Tedeschi G , Netti PA , Abrescia P . The level of 24-hydroxycholesteryl esters decreases in plasma of patients with Parkinson's disease. Neurosci Lett, 2018, 672: 108- 112.
doi: 10.1016/j.neulet.2018.02.041
|
| 16 |
Rosner S , Giladi N , Orr-Urtreger A . Advances in the genetics of Parkinson's disease. Acta Pharmacol Sin, 2008, 29: 21- 34.
doi: 10.1111/j.1745-7254.2008.00731.x
|
| 17 |
Jia F , Fellner A , Kumar KR . Monogenic Parkinson's disease: genotype, phenotype, pathophysiology, and genetic testing. Genes (Basel), 2022, 13: 471.
doi: 10.3390/genes13030471
|
| 18 |
Fais M , Dore A , Galioto M , Galleri G , Crosio C , Iaccarino C . Parkinson's disease: related genes and lipid alteration. Int J Mol Sci, 2021, 22: 7630.
doi: 10.3390/ijms22147630
|
| 19 |
Alecu I , Bennett SAL . Dysregulated lipid metabolism and its role in α-synucleinopathy in Parkinson's disease. Front Neurosci, 2019, 13: 328.
doi: 10.3389/fnins.2019.00328
|
| 20 |
Sánchez Campos S , Alza NP , Salvador GA . Lipid metabolism alterations in the neuronal response to A53T α-synuclein and Fe-induced injury. Arch Biochem Biophys, 2018, 655: 43- 54.
doi: 10.1016/j.abb.2018.08.007
|
| 21 |
Fanning S , Haque A , Imberdis T , Baru V , Barrasa MI , Nuber S , Termine D , Ramalingam N , Ho GPH , Noble T , Sandoe J , Lou Y , Landgraf D , Freyzon Y , Newby G , Soldner F , Terry-Kantor E , Kim TE , Hofbauer HF , Becuwe M , Jaenisch R , Pincus D , Clish CB , Walther TC , Farese RV Jr , Srinivasan S , Welte MA , Kohlwein SD , Dettmer U , Lindquist S , Selkoe D . Lipidomic analysis of α-synuclein neurotoxicity identifies stearoyl CoA desaturase as a target for Parkinson treatment. Mol Cell, 2019, 73: 1001- 1014. e8.
doi: 10.1016/j.molcel.2018.11.028
|
| 22 |
Bae EJ , Lee HJ , Jang YH , Michael S , Masliah E , Min DS , Lee SJ . Phospholipase D1 regulates autophagic flux and clearance of α-synuclein aggregates. Cell Death Differ, 2014, 21: 1132- 1141.
doi: 10.1038/cdd.2014.30
|
| 23 |
Stoker TB , Camacho M , Winder-Rhodes S , Liu G , Scherzer CR , Foltynie T , Evans J , Breen DP , Barker RA , Williams-Gray CH . Impact of GBA1 variants on long-term clinical progression and mortality in incident Parkinson's disease. J Neurol Neurosurg Psychiatry, 2020, 91: 695- 702.
doi: 10.1136/jnnp-2020-322857
|
| 24 |
Stok R , Ashkenazi A . Lipids as the key to understanding α-synuclein behaviour in Parkinson disease. Nat Rev Mol Cell Biol, 2020, 21: 357- 358.
doi: 10.1038/s41580-020-0235-y
|
| 25 |
Blandini F , Cilia R , Cerri S , Pezzoli G , Schapira AHV , Mullin S , Lanciego JL . Glucocerebrosidase mutations and synucleinopathies: toward a model of precision medicine. Mov Disord, 2019, 34: 9- 21.
doi: 10.1002/mds.27583
|
| 26 |
Sardi SP , Viel C , Clarke J , Treleaven CM , Richards AM , Park H , Olszewski MA , Dodge JC , Marshall J , Makino E , Wang B , Sidman RL , Cheng SH , Shihabuddin LS . Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models. Proc Natl Acad Sci USA, 2017, 114: 2699- 2704.
doi: 10.1073/pnas.1616152114
|
| 27 |
Galper J , Kim WS , Dzamko N . LRRK2 and lipid pathways: implications for Parkinson's disease. Biomolecules, 2022, 12: 1597.
doi: 10.3390/biom12111597
|
| 28 |
Fang Z , Liu G , Zhu M , Wang S , Jiang Q , Loor JJ , Yu H , Hao X , Chen M , Gao W , Lei L , Song Y , Wang Z , Du X , Li X . Low abundance of mitophagy markers is associated with reactive oxygen species overproduction in cows with fatty liver and causes reactive oxygen species overproduction and lipid accumulation in calf hepatocytes. J Dairy Sci, 2022, 105: 7829- 7841.
doi: 10.3168/jds.2021-21774
|
| 29 |
Vos DY , Heida A , Koster M , Tissink J , Kuentzel KB , Kloosterhuis NJ , Smit M , Huijkman N , Reggiori F , Mari M , Scheja L , Heeren J , Kratky D , Kuivenhoven J , Van De Sluis B . The endosomal sorting protein VPS35 controls lipid homeostasis through regulating hepatic lysosomal function. Atherosclerosis, 2022, 355: 19- 20.
|
| 30 |
Yamaguchi S , Yamane T , Takahashi-Niki K , Kato I , Niki T , Goldberg MS , Shen J , Ishimoto K , Doi T , Iguchi-Ariga SM , Ariga H . Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis. PLoS One, 2012, 7: e38144.
doi: 10.1371/journal.pone.0038144
|
| 31 |
Mustapha M , Mat Taib CN . MPTP-induced mouse model of Parkinson's disease: a promising direction of therapeutic strategies. Bosn J Basic Med Sci, 2021, 21: 422- 433.
|
| 32 |
Tong T , Duan W , Xu Y , Hong H , Xu J , Fu G , Wang X , Yang L , Deng P , Zhang J , He H , Mao G , Lu Y , Lin X , Yu Z , Pi H , Cheng Y , Xu S , Zhou Z . Paraquat exposure induces parkinsonism by altering lipid profile and evoking neuroinflammation in the midbrain. Environ Int, 2022, 169: 107512.
doi: 10.1016/j.envint.2022.107512
|
| 33 |
Ge X , Ye G , He J , Bao Y , Zheng Y , Cheng H , Feng X , Yang W , Wang F , Zou Y , Yang X . Metal mixtures with longitudinal changes in lipid profiles: findings from the manganese-exposed workers healthy cohort. Environ Sci Pollut Res Int, 2022, 29: 85103- 85113.
doi: 10.1007/s11356-022-21653-5
|
| 34 |
Villalón-García I , Povea-Cabello S , Álvarez-Córdoba M , Talaverón-Rey M , Suárez-Rivero JM , Suárez-Carrillo A , Munuera-Cabeza M , Reche-López D , Cilleros-Holgado P , Piñero-Pérez R , Sánchez-Alcázar JA . Vicious cycle of lipid peroxidation and iron accumulation in neurodegeneration. Neural Regen Res, 2023, 18: 1196- 1202.
doi: 10.4103/1673-5374.358614
|
| 35 |
Kalia LV , Lang AE . Parkinson's disease. Lancet, 2015, 386: 896- 912.
doi: 10.1016/S0140-6736(14)61393-3
|
| 36 |
Patel R , Kompoliti K . Sex and gender differences in Parkinson's disease. Neurol Clin, 2023, 41: 371- 379.
doi: 10.1016/j.ncl.2022.12.001
|
| 37 |
Lehmann J , Caduff N , Krzywińska E , Stierli S , Salas-Bastos A , Loos B , Levesque MP , Dummer R , Stockmann C , Münz C , Diener J , Sommer L . Escape from NK cell tumor surveillance by NGFR-induced lipid remodeling in melanoma. Sci Adv, 2023, 9: eadc8825.
doi: 10.1126/sciadv.adc8825
|
| 38 |
Zhang X , Fan Y , Luo Y , Jin L , Li S . Lipid metabolism is the common pathologic mechanism between type 2 diabetes mellitus and Parkinson's disease. Int J Med Sci, 2020, 17: 1723- 1732.
doi: 10.7150/ijms.46456
|
| 39 |
Yu HY , Sun T , Wang Z , Li H , Xu D , An J , Wen LL , Li JY , Li W , Feng J . Exendin-4 and linagliptin attenuate neuroinflammation in a mouse model of Parkinson's disease. Neural Regen Res, 2023, 18: 1818- 1826.
|
| 40 |
Guimarães RP , Ribeiro DL , Dos Santos KB , Godoy LD , Corrêa MR , Padovan-Neto FE . The 6-hydroxydopamine rat model of Parkinson's disease. J Vis Exp, 2021, PMID34779439.
|
| 41 |
Qiu J , Peng G , Tang Y , Li S , Liu Z , Zheng J , Wang Y , Liu H , Wei L , Su Y , Lin Y , Dai W , Zhang Z , Chen X , Ding L , Guo W , Zhu X , Xu P , Mo M . Lipid profiles in the cerebrospinal fluid of rats with 6-hydroxydopamine-induced lesions as a model of Parkinson's disease. Front Aging Neurosci, 2023, 14: 1077738.
doi: 10.3389/fnagi.2022.1077738
|
| 42 |
Pierzchlińska A , Droździk M , Białecka M . A possible role for HMG -CoA reductase inhibitors and its association with HMGCR genetic variation in Parkinson's disease. Int J Mol Sci, 2021, 22: 12198.
doi: 10.3390/ijms222212198
|
| 43 |
Dou T , Kurouski D . Phosphatidylcholine and phosphatidylserine uniquely modify the secondary structure of α-synuclein oligomers formed in their presence at the early stages of protein aggregation. ACS Chem Neurosci, 2022, 13: 2380- 2385.
doi: 10.1021/acschemneuro.2c00355
|
| 44 |
Fusco G , Chen SW , Williamson PTF , Cascella R , Perni M , Jarvis JA , Cecchi C , Vendruscolo M , Chiti F , Cremades N , Ying L , Dobson CM , De Simone A . Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers. Science, 2017, 358: 1440- 1443.
doi: 10.1126/science.aan6160
|
| 45 |
Dai L , Wang J , Zhang X , Yan M , Zhou L , Zhang G , Meng L , Chen L , Cao X , Zhang Z , Wang G , Zhang Z . 27-hydroxycholesterol drives the spread of α-synuclein pathology in Parkinson's disease. Mov Disord, 2023, 38: 2005- 2018.
doi: 10.1002/mds.29577
|
| 46 |
Chen K , Martens YA , Meneses A , Ryu DH , Lu W , Raulin AC , Li F , Zhao J , Chen Y , Jin Y , Linares C , Goodwin M , Li Y , Liu CC , Kanekiyo T , Holtzman DM , Golde TE , Bu G , Zhao N . LRP1 is a neuronal receptor for α -synuclein uptake and spread. Mol Neurodegener, 2022, 17: 57.
doi: 10.1186/s13024-022-00560-w
|
| 47 |
Riederer P , Nagatsu T , Youdim MBH , Wulf M , Dijkstra JM , Sian-Huelsmann J . Lewy bodies, iron, inflammation and neuromelanin: pathological aspects underlying Parkinson's disease. J Neural Transm (Vienna), 2023, 130: 627- 646.
doi: 10.1007/s00702-023-02630-9
|
| 48 |
Mahoney-Sánchez L , Bouchaoui H , Ayton S , Devos D , Duce JA , Devedjian JC . Ferroptosis and its potential role in the physiopathology of Parkinson's disease. Prog Neurobiol, 2021, 196: 101890.
doi: 10.1016/j.pneurobio.2020.101890
|
| 49 |
Brauer R , Bhaskaran K , Chaturvedi N , Dexter DT , Smeeth L , Douglas I . Glitazone treatment and incidence of Parkinson′s disease among people with diabetes: a retrospective cohort study. PLoS Med, 2015, 12: e1001854.
doi: 10.1371/journal.pmed.1001854
|
| 50 |
Xin S , Schick JA . PUFAs dictate the balance of power in ferroptosis. Cell Calcium, 2023, 110: 102703.
doi: 10.1016/j.ceca.2023.102703
|
| 51 |
Lu DH. Mechanism of ferroptosis in dopaminergic neurons: α-synuclein-induced phospholipid peroxidation[D]. Guangzhou: Ji'nan University, 2020.
|
|
卢单华. 多巴胺能神经元的铁死亡机制: α-突触核蛋白诱导的磷脂过氧化[D]. 广州: 暨南大学, 2020.
|
| 52 |
Hirayama M , Ohno K . Parkinson's disease and gut microbiota. Ann Nutr Metab, 2021, 77 (Suppl 2): 28- 35.
|
| 53 |
Toomey CE , Heywood WE , Evans JR , Lachica J , Pressey SN , Foti SC , Al Shahrani M , D'Sa K , Hargreaves IP , Heales S , Orford M , Troakes C , Attems J , Gelpi E , Palkovits M , Lashley T , Gentleman SM , Revesz T , Mills K , Gandhi S . Mitochondrial dysfunction is a key pathological driver of early stage Parkinson's. Acta Neuropathol Commun, 2022, 10: 134.
doi: 10.1186/s40478-022-01424-6
|
| 54 |
Imberechts D , Vandenberghe W . Defects in PINK-PRKN-PARK7/DJ-1-dependent mitophagy and autosomal recessive Parkinson disease. Autophagy, 2023, 19: 1872- 1873.
doi: 10.1080/15548627.2022.2139129
|
| 55 |
Fernandes HJR , Kent JP , Bruntraeger M , Bassett AR , Koulman A , Metzakopian E , Snowden SG . Mitochondrial and endoplasmic reticulum stress trigger triglyceride accumulation in models of Parkinson's disease independent of mutations in MAPT. Metabolites, 2023, 13: 112.
doi: 10.3390/metabo13010112
|
| 56 |
Zhang X , Xu S , Hu Y , Liu Q , Liu C , Chai H , Luo Y , Jin L , Li S . Irisin exhibits neuroprotection by preventing mitochondrial damage in Parkinson's disease. NPJ Parkinsons Dis, 2023, 9: 13.
doi: 10.1038/s41531-023-00453-9
|
| 57 |
Liu C , Chen J , Chen H , Zhang T , He D , Luo Q , Chi J , Hong Z , Liao Y , Zhang S , Wu Q , Cen H , Chen G , Li J , Wang L . PCSK9 inhibition: from current advances to evolving future. Cells, 2022, 11: 2972.
doi: 10.3390/cells11192972
|
| 58 |
Jahed MR , Habibi SAH , Vaseghi G , Amiri H , Montazeri H , Eshraghi A . Association between plasma PCSK9 levels and lipid profile in patients with Parkinson's disease and comparison with healthy subjects. Curr J Neurol, 2022, 21: 236- 243.
|