中国现代神经疾病杂志 ›› 2023, Vol. 23 ›› Issue (10): 889-895. doi: 10.3969/j.issn.1672-6731.2023.10.004

• 专题综述 • 上一篇    下一篇

2 颅脑创伤后泛素-蛋白酶体系统和自噬系统机制研究进展

温兆孟1, 刘文虎1, 梁金2, 刘建雄2,*()   

  1. 1. 730000 兰州, 甘肃中医药大学第一临床医学院2021级
    2. 730000 兰州, 甘肃省人民医院神经外科
  • 收稿日期:2023-07-02 出版日期:2023-10-25 发布日期:2023-10-31
  • 通讯作者: 刘建雄
  • 基金资助:
    甘肃省科技计划项目(21JR1RA019); 甘肃省人民医院院内科研基金资助项目(20GSSY3-16)

Research progress on the interaction mechanism between ubiquitin-proteasome system and autophagy system after traumatic brain injury

Zhao-meng WEN1, Wen-hu LIU1, Jin LIANG2, Jian-xiong LIU2,*()   

  1. 1. Grade 2021, The First Clinical Medical College of Gansu University of Chinese Medicine, Lanzhou 730000, Gansu, China
    2. Depatment of Neurosurgery, Gansu Provincial Hospital, Lanzhou 730000, Gansu, China
  • Received:2023-07-02 Online:2023-10-25 Published:2023-10-31
  • Contact: Jian-xiong LIU
  • Supported by:
    Gansu Provincial Science and Technology Plan Project(21JR1RA019); Scientific Research Fund of Gansu Provincial Hospital(20GSSY3-16)

摘要:

泛素-蛋白酶体系统和自噬系统是真核生物蛋白质质量控制的两个系统,二者既可独立发挥生物学作用,又存在密切关联,在颅脑创伤后清除异常蛋白质与神经细胞继发性损伤机制中发挥关键作用。本文综述颅脑创伤后神经细胞继发性损伤中泛素-蛋白酶体系统和自噬系统的作用机制及交互作用,为颅脑创伤后神经功能保护和预后改善提供理论依据。

关键词: 脑损伤, 创伤性, 泛素, 自噬, 综述

Abstract:

The ubiquitin - proteasome system (UPS) and autophagy system are two systems in eukaryotic protein quality control, both of which can play a biological role independently and also closely related, and play a key role in clearing abnormal proteins and secondary injury mechanism of nerve cells after traumatic brain injury (TBI). This article reviews the mechanism and interaction of UPS and autophagy system in secondary injury after TBI, in order to provide theoretical basis for protecting nerve function and improving prognosis after TBI.

Key words: Brain injuries, traumatic, Ubiquitin, Autophagy, Review