摘要： 重症脑静脉系统血栓形成（CVT）是脑卒中的罕见类型，患者大多预后不良且病死率较高。目前对重症CVT病理生理学机制的了解仅限于静脉回流障碍所致，对其发生发展过程知之甚少。近年针对炎症与重症CVT关系的研究显示，炎症参与重症CVT的发生发展全过程，且多种炎性标志物与患者预后不良密切相关，提示靶向炎症治疗重症CVT是颇具前景的方案。本文概述炎症与重症CVT相关基础与临床研究进展，旨在了解炎症在重症CVT病理生理学机制中的角色，以为制定新的治疗策略提供思路。

关键词: 炎症, 颅内血栓形成, 脑静脉, 综述

Abstract: Severe cerebral venous thrombosis (CVT) is a rare type of stroke with poor prognosis and high mortality. The pathophysiological mechanism of severe CVT at present only focus on the onslaught of CVT as a venous return disorder and fails to elucidate the process of occurrence and development of the disease. Recently, studies on the relationship between severe CVT and inflammation have found that inflammation is involved in the pathophysiology of severe CVT, and a variety of inflammatory markers are correlated with its poor prognosis, suggesting that targeted inflammation therapy for severe CVT is a very promising treatment. This paper reviews the basic and clinical research on the relationship between inflammation and severe CVT to understand the role of inflammation in the pathophysiology of severe CVT and provide ideas for the development of new treatment strategies for severe CVT.

Key words: Inflammation, Intracranial thrombosis, Cerebral veins, Review