中国现代神经疾病杂志 ›› 2022, Vol. 22 ›› Issue (1): 23-30. doi: 10.3969/j.issn.1672-6731.2022.01.004

• 炎症与神经系统疾病 • 上一篇    下一篇

2 基于“责任抗体”概念的自身免疫性脑炎诊断与治疗进展

陈向军   

  1. 200040 上海,复旦大学附属华山医院神经内科 国家神经疾病医学中心 复旦大学神经病学研究所
  • 收稿日期:2022-01-07 出版日期:2022-01-25 发布日期:2022-01-22
  • 作者简介:陈向军,E-mail:xiangjchen@fudan.edu.cn
  • 基金资助:
    上海申康医院发展中心促进市级医院临床技能与临床创新能力三年行动计划(项目编号:SHDC2020CR2027B);上海市卫生健康委2020年中央转移支付医疗卫生机构能力建设项目/国家和省级重大疾病多学科合作诊疗能力建设项目

"Culprit antibody" concept based diagnosis and treatment strategy of autoimmune encephalitis

CHEN Xiang-jun   

  1. Department of Neurology, Huashan Hospital, Fudan University; National Center for Neurological Disorders; Institute of Neurology, Fudan University, Shanghai 200040, China
  • Received:2022-01-07 Online:2022-01-25 Published:2022-01-22
  • Supported by:
    This study was supported by the Clinical Three-year Action Plan of SHDC (No. SHDC2020CR2027B), and Shanghai Municipal Health Commission 2020 Central Transfer Payment Capacity Building Project for Medical Besieged Institutions/National and Provincial Capacity Building Project for Multi - Scientific Cooperation in Diagnosis and Treatment of Major Diseases

摘要: 自身免疫性脑炎是神经系统免疫性疾病的重要组成之一,存在靶向神经元表面蛋白、离子通道或突触表面受体的自身抗体,自身抗体检测对疾病的诊断、治疗及预后评估具有重要意义。确定责任抗体是解决同一例患者多种自身抗体共存的重要方法,本文基于新近提出的“责任抗体”概念对自身免疫性脑炎诊断与治疗进展进行综述。

关键词: 脑炎, 自身免疫疾病, 抗体, 综述

Abstract: Autoimmune encephalitis (AE) with autoantibodies targeting neuronal surface proteins, ion channels or synaptic surface receptors is a major component of neuroimmune diseases. The detection of autoantibodies is of great value for the diagnosis, treatment and prognosis. Culprit antibody solve the problem of the coexistence of different autoantibodies in the same patient. This article review the relationship between culprit antibody and clinical phenotype in AE.

Key words: Encephalitis, Autoimmune diseases, Antibodies, Review