中国现代神经疾病杂志 ›› 2021, Vol. 21 ›› Issue (9): 751-763. doi: 10.3969/j.issn.1672-6731.2021.09.005

• 2021年WHO中枢神经系统肿瘤分类(第五版)解读 • 上一篇    下一篇

2 2021年世界卫生组织中枢神经系统肿瘤分类(第五版)分子诊断指标解读

刘幸, 陈慧媛, 邹婉婧, 李桂林   

  1. 100070 北京市神经外科研究所神经病理室
  • 收稿日期:2021-09-01 出版日期:2021-09-25 发布日期:2021-10-09
  • 通讯作者: 李桂林,Email:liguilin40@hotmail.com

Interpretation on the diagnostic molecular parameters in the 2021 WHO Classification of Tumors of the Central Nervous System (fifth edition)

LIU Xing, CHEN Hui-yuan, ZOU Wan-jing, LI Gui-lin   

  1. Department of Neuropatholoy, Beijing Neurosurgical Institute, Beijing 100070, China
  • Received:2021-09-01 Online:2021-09-25 Published:2021-10-09
  • Contact: 10.3969/j.issn.1672-6731.2021.09.005

摘要:

2021年世界卫生组织中枢神经系统肿瘤分类(第五版,简称新版肿瘤分类)在组织学诊断的基础上引入一系列分子诊断指标,形成整合诊断及分层报告体系,并新定义多种肿瘤类型和亚型,反映出目前神经肿瘤相关领域对此类疾病遗传背景和临床特征的理解。本文综述新版肿瘤分类关键的分子诊断指标及相应检测方法,旨在为临床认识疾病、管理肿瘤患者提供帮助。

关键词: 中枢神经系统肿瘤, 指南, 世界卫生组织, 分子生物学, 基因, 突变, 综述

Abstract:

The 2021 WHO Classification of Tumors of the Central Nervous System (fifth edition) introduces a series of molecular biomarkers and new types/subtypes, which highlight the importance of integrated diagnoses and layered reports. The new edition tumors classification is reflections of the understanding in this field at present. Herein, we review the key molecular diagnostics and detection techniques, aiming to facilitate better understanding and more appropriate management for the tumors of the central nervous system.

Key words: Central nervous system neoplasms, Guidelines, World Health Organization, Molecular biology, Genes, Mutation, Review