[1] Kim HW, Hong J, Jeon JC. Cerebral small vessel disease and Alzheimer's disease:a review[J]. Front Neurol, 2020, 11:927.
[2] Tay J, Morris RG, Markus HS. Apathy after stroke:diagnosis, mechanisms, consequences, and treatment[J]. Int J Stroke, 2021.[Epub ahead of print]
[3] van der Holst HM, van Uden IW, Tuladhar AM, de Laat KF, van Norden AG, Norris DG, van Dijk EJ, Esselink RA, Platel B, de Leeuw FE. Cerebral small vessel disease and incident parkinsonism:the RUN DMC study[J]. Neurology, 2015, 85:1569-1577.
[4] Wardlaw JM, Smith EE, Biessels GJ, Cordonnier C, Fazekas F, Frayne R, Lindley RI, O'Brien JT, Barkhof F, Benavente OR, Black SE, Brayne C, Breteler M, Chabriat H, Decarli C, de Leeuw FE, Doubal F, Duering M, Fox NC, Greenberg S, Hachinski V, Kilimann I, Mok V, Oostenbrugge Rv, Pantoni L, Speck O, Stephan BC, Teipel S, Viswanathan A, Werring D, Chen C, Smith C, van Buchem M, Norrving B, Gorelick PB, Dichgans M; STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1). Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration[J]. Lancet Neurol, 2013, 12:822-838.
[5] Cannistraro RJ, Badi M, Eidelman BH, Dickson DW, Middlebrooks EH, Meschia JF. CNS small vessel disease:a clinical review[J]. Neurology, 2019, 92:1146-1156.
[6] Li T, Huang Y, Cai W, Chen X, Men X, Lu T, Wu A, Lu Z. Age-related cerebral small vessel disease and inflammaging[J]. Cell Death Dis, 2020, 11:932.
[7] Low A, Mak E, Rowe JB, Markus HS, O'Brien JT. Inflammation and cerebral small vessel disease:a systematic review[J]. Ageing Res Rev, 2019, 53:100916.
[8] Wardlaw JM, Smith C, Dichgans M. Small vessel disease:mechanisms and clinical implications[J]. Lancet Neurol, 2019, 18:684-696.
[9] Jandke S, Garz C, Schwanke D, Sendtner M, Heinze HJ, Carare RO, Schreiber S. The association between hypertensive arteriopathy and cerebral amyloid angiopathy in spontaneously hypertensive stroke-prone rats[J]. Brain Pathol, 2018, 28:844-859.
[10] Grochowski C, Litak J, Kamieniak P, Maciejewski R. Oxidative stress in cerebral small vessel disease:role of reactive species[J]. Free Radic Res, 2018, 52:1-13.
[11] Libby P. Mechanisms of acute coronary syndromes and their implications for therapy[J]. N Engl J Med, 2013, 368:2004-2013.
[12] Tomiyama H, Shiina K, Matsumoto-Nakano C, Ninomiya T, Komatsu S, Kimura K, Chikamori T, Yamashina A. The contribution of inflammation to the development of hypertension mediated by increased arterial stiffness[J]. J Am Heart Assoc, 2017, 6:e005729.
[13] Zhang D, Frenette PS. Cross talk between neutrophils and the microbiota[J]. Blood, 2019, 133:2168-2177.
[14] Liberale L, Montecucco F, Tardif JC, Libby P, Camici GG. Inflamm-ageing:the role of inflammation in age-dependent cardiovascular disease[J]. Eur Heart J, 2020, 41:2974-2982.
[15] Schuldt A, Assmann T, Brezzi M, Buscot F, Eichenberg D, Gutknecht J, Härdtle W, He JS, Klein AM, Kühn P, Liu X, Ma K, Niklaus PA, Pietsch KA, Purahong W, Scherer-Lorenzen M, Schmid B, Scholten T, Staab M, Tang Z, Trogisch S, von Oheimb G, Wirth C, Wubet T, Zhu CD, Bruelheide H. Biodiversity across trophic levels drives multifunctionality in highly diverse forests[J]. Nat Commun, 2018, 9:2989.
[16] Koren O, Spor A, Felin J, Fåk F, Stombaugh J, Tremaroli V, Behre CJ, Knight R, Fagerberg B, Ley RE, Bäckhed F. Human oral, gut, and plaque microbiota in patients with atherosclerosis[J]. Proc Natl Acad Sci USA, 2011, 108 Suppl 1:4592-4598.
[17] Liberale L, Diaz-Cañestro C, Bonetti NR, Paneni F, Akhmedov A, Beer JH, Montecucco F, Lüscher TF, Camici GG. Post-ischaemic administration of the murine Canakinumab-surrogate antibody improves outcome in experimental stroke[J]. Eur Heart J, 2018, 39:3511-3517.
[18] van Dijk EJ, Prins ND, Vermeer SE, Vrooman HA, Hofman A, Koudstaal PJ, Breteler MM. C-reactive protein and cerebral small-vessel disease:the Rotterdam Scan Study[J]. Circulation, 2005, 112:900-905.
[19] Walker KA, Windham BG, Power MC, Hoogeveen RC, Folsom AR, Ballantyne CM, Knopman DS, Selvin E, Jack CR Jr, Gottesman RF. The association of mid-to late-life systemic inflammation with white matter structure in older adults:the Atherosclerosis Risk in Communities Study[J]. Neurobiol Aging, 2018, 68:26-33.
[20] Noz MP, Ter Telgte A, Wiegertjes K, Joosten LAB, Netea MG, de Leeuw FE, Riksen NP. Trained immunity characteristics are associated with progressive cerebral small vessel disease[J]. Stroke, 2018, 49:2910-2917.
[21] Chen Y, Pitzer AL, Li X, Li PL, Wang L, Zhang Y. Instigation of endothelial Nlrp3 inflammasome by adipokine visfatin promotes inter-endothelial junction disruption:role of HMGB1[J]. J Cell Mol Med, 2015, 19:2715-2727.
[22] Quigley EMM. Microbiota-brain-gut axis and neurodegenerative diseases[J]. Curr Neurol Neurosci Rep, 2017, 17:94.
[23] Zhao Y, Lukiw WJ. Microbiome-generated amyloid and potential impact on amyloidogenesis in Alzheimer's disease (AD)[J]. J Nat Sci, 2015, 1:e138.
[24] Köhler CA, Maes M, Slyepchenko A, Berk M, Solmi M, Lanctôt KL, Carvalho AF. The gut-brain axis, including the microbiome, leaky gut and bacterial translocation:mechanisms and pathophysiological role in Alzheimer's disease[J]. Curr Pharm Des, 2016, 22:6152-6166.
[25] Cai W, Chen X, Men X, Ruan H, Hu M, Liu S, Lu T, Liao J, Zhang B, Lu D, Huang Y, Fan P, Rao J, Lei C, Wang J, Ma X, Zhu Q, Li L, Zhu X, Hou Y, Li S, Dong Q, Tian Q, Ai L, Luo W, Zuo M, Shen L, Xie C, Song H, Xu G, Zheng K, Zhang Z, Lu Y, Qiu W, Chen T, Xiang AP, Lu Z. Gut microbiota from patients with arteriosclerotic CSVD induces higher IL-17A production in neutrophils via activating RORγt[J]. Sci Adv, 2021, 7:eabe4827.
[26] Ter Telgte A, van Leijsen EMC, Wiegertjes K, Klijn CJM, Tuladhar AM, de Leeuw FE. Cerebral small vessel disease:from a focal to a global perspective[J]. Nat Rev Neurol, 2018, 14:387-398.
[27] Calder PC, Bosco N, Bourdet-Sicard R, Capuron L, Delzenne N, Doré J, Franceschi C, Lehtinen MJ, Recker T, Salvioli S, Visioli F. Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition[J]. Ageing Res Rev, 2017, 40:95-119.
[28] Riera Romo M, Pérez-Martínez D, Castillo Ferrer C. Innate immunity in vertebrates:an overview[J]. Immunology, 2016, 148:125-139.
[29] Shoamanesh A, Preis SR, Beiser AS, Vasan RS, Benjamin EJ, Kase CS, Wolf PA, DeCarli C, Romero JR, Seshadri S. Inflammatory biomarkers, cerebral microbleeds, and small vessel disease:Framingham Heart Study[J]. Neurology, 2015, 84:825-832.
[30] Moore KJ, Sheedy FJ, Fisher EA. Macrophages in atherosclerosis:a dynamic balance[J]. Nat Rev Immunol, 2013, 13:709-721.
[31] Splunter MV, Perdijk O, Fick-Brinkhof H, Floris-Vollenbroek EG, Meijer B, Brugman S, Savelkoul HFJ, van Hoffen E, Joost van Neerven RJ. Plasmacytoid dendritic cell and myeloid dendritic cell function in ageing:a comparison between elderly and young adult women[J]. PLoS One, 2019, 14:e0225825.
[32] Ronaldson PT, Davis TP. Blood-brain barrier integrity and glial support:mechanisms that can be targeted for novel therapeutic approaches in stroke[J]. Curr Pharm Des, 2012, 18:3624-3644.
[33] Hu X, De Silva TM, Chen J, Faraci FM. Cerebral vascular disease and neurovascular injury in ischemic stroke[J]. Circ Res, 2017, 120:449-471.
[34] Jian B, Hu M, Cai W, Zhang B, Lu Z. Update of immunosenescence in cerebral small vessel disease[J]. Front Immunol, 2020, 11:585655.
[35] Engelhardt B, Carare RO, Bechmann I, Flügel A, Laman JD, Weller RO. Vascular, glial, and lymphatic immune gateways of the central nervous system[J]. Acta Neuropathol, 2016, 132:317-338.
[36] Ryu JK, Petersen MA, Murray SG, Baeten KM, Meyer-Franke A, Chan JP, Vagena E, Bedard C, Machado MR, Rios Coronado PE, Prod'homme T, Charo IF, Lassmann H, Degen JL, Zamvil SS, Akassoglou K. Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation[J]. Nat Commun, 2015, 6:8164.
[37] Frasca D, Blomberg BB. Adipose tissue inflammation induces B cell inflammation and decreases B cell function in aging[J]. Front Immunol, 2017, 8:1003.
[38] Becker KJ, Kalil AJ, Tanzi P, Zierath DK, Savos AV, Gee JM, Hadwin J, Carter KT, Shibata D, Cain KC. Autoimmune responses to the brain after stroke are associated with worse outcome[J]. Stroke, 2011, 42:2763-2769.
[39] Becker KJ, Zierath D, Kunze A, Fecteau L, Lee B, Skerrett S. The contribution of antibiotics, pneumonia and the immune response to stroke outcome[J]. J Neuroimmunol, 2016, 295-296:68-74.
[40] Ren X, Akiyoshi K, Grafe MR, Vandenbark AA, Hurn PD, Herson PS, Offner H. Myelin specific cells infiltrate MCAO lesions and exacerbate stroke severity[J]. Metab Brain Dis, 2012, 27:7-15.
[41] Fu Y, Yan Y. Emerging role of immunity in cerebral small vessel disease[J]. Front Immunol, 2018, 9:67.