中国现代神经疾病杂志 ›› 2021, Vol. 21 ›› Issue (5): 339-344. doi: 10.3969/j.issn.1672-6731.2021.05.002

• 专题综述 • 上一篇    下一篇

2 人类免疫缺陷病毒相关神经系统疾病研究进展

代飞飞1, 王佳伟1,2   

  1. 1 100730 首都医科大学附属北京同仁医院神经内科;
    2 100730 首都医科大学附属北京同仁医院中心实验室
  • 收稿日期:2021-05-19 出版日期:2021-05-25 发布日期:2021-05-28
  • 通讯作者: 王佳伟,Email:wangjwcq@163.com

Progress in HIV-related nervous system diseases

DAI Fei-fei1, WANG Jia-wei1,2   

  1. 1 Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China;
    2 Medical Research Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
  • Received:2021-05-19 Online:2021-05-25 Published:2021-05-28

摘要:

自联合抗逆转录病毒疗法应用后,人类免疫缺陷病毒(HIV)相关神经系统疾病的流行病学和疾病谱发生较大变化。较常见的是HIV相关神经综合征,包括原发感染、机会性感染、免疫重建炎症综合征、抗逆转录病毒药物相关神经毒性作用等;以及老龄化相关疾病,包括HIV相关神经认知障碍、HIV相关脑血管病、HIV相关周围神经病等。本文综述HIV相关神经系统疾病的研究进展,有助于临床医师早期识别、及时诊断与治疗。

关键词: HIV, 神经系统疾病, 抗病毒药, 逆转录病毒科, 综述

Abstract:

Since combination antiretroviral therapy (cART) appeared, the epidemiology and spectrum of human immunodeficiency virus (HIV)-related nervous system diseases have changed significantly. HIV-related neurological syndromes are more common, including primary infection, opportunistic infection, immune reconstitution inflammatory syndrome, antiretroviral -drugs related neurotoxic effects, etc; and aging-related diseases, including HIV-associated neurocognitive disorder (HAND), HIV-related cerebrovascular diseases, and HIV-related peripheral neuropathy. This article reviews the research progress of HIV -related nervous system diseases, which is helpful for clinicians to recognize early, diagnose and treat in time.

Key words: HIV, Nervous system diseases, Antiviral agents, Retroviridae, Review