衰弱合并脑血管病研究进展

doi:10.3969/j.issn.1672-6731.2021.01.007

中国现代神经疾病杂志 ›› 2021, Vol. 21 ›› Issue (1): 30-33. doi: 10.3969/j.issn.1672-6731.2021.01.007

2 衰弱合并脑血管病研究进展

赵瑞雪¹, 马雅军¹, 李晓东¹, 王笑峰², 蒋晓燕³, 李淑娟¹

1 100020 首都医科大学附属北京朝阳医院神经内科;
2 200433 上海,复旦大学人类表型组研究院现代人类学教育部重点实验室;
3 200092 上海,同济大学医学院病理学与病理生理学系

收稿日期:2021-01-05 出版日期:2021-01-25 发布日期:2021-01-22
通讯作者: 李淑娟,Email:2431965@qq.com
基金资助:
国家重点研发计划项目（项目编号：2018YFC2000400）；国家重点研发计划项目（项目编号：2018YFC2002000）；国家自然科学基金资助项目（项目编号：81971102）

Research progress of frailty complicated with cerebrovascular disease

ZHAO Rui-xue¹, MA Ya-jun¹, LI Xiao-dong¹, WANG Xiao-feng², JIANG Xiao-yan³, LI Shu-juan¹

1 Department of Neurology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China;
2 Ministry of Education Key Laboratory of Contemporary Anthropology, Human Phenome Institute, Fudan University, Shanghai 200433, China;
3 Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai 200092, China

Received:2021-01-05 Online:2021-01-25 Published:2021-01-22
Supported by:
This study was supported by the National Key Research and Development Program (No. 2018YFC2000400, 2018YFC2002000) and the National Natural Science Foundation of China (No. 81971102).

摘要/Abstract

摘要：

衰弱系多系统生理储备和功能下降导致的老年综合征，使老年人对内外环境的应激能力和维持稳态能力下降，并使不良事件风险增加。其中以脑卒中患者衰弱和衰弱前期发生率最高且明显高于非脑卒中患者，而衰弱人群脑血管病患病率亦显著增加且预后不良。本文拟对衰弱与脑血管病之间的潜在关联性进行综述。

关键词: 蛋白质能量营养不良, 卒中, 老年人, 综述

Abstract:

Frailty is a geriatric syndrome caused by a decrease in multi-system physiological reserve and function, which reduces the elderly's ability to stress the internal and external environment and maintain homeostasis, and increases the risk of adverse health events. The incidence of frailty and pre-frailty in stroke patients is the highest and significantly higher than that in non-stroke patients, while the prevalence of cerebrovascular disease in frailty patients is also significantly increased and the prognosis is worse. This paper intends to review the potential association between frailty and cerebrovascular disease.

Key words: Protein-energy malnutrition, Stroke, Aged, Review

赵瑞雪, 马雅军, 李晓东, 王笑峰, 蒋晓燕, 李淑娟. 衰弱合并脑血管病研究进展[J]. 中国现代神经疾病杂志, 2021, 21(1): 30-33.

ZHAO Rui-xue, MA Ya-jun, LI Xiao-dong, WANG Xiao-feng, JIANG Xiao-yan, LI Shu-juan. Research progress of frailty complicated with cerebrovascular disease[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2021, 21(1): 30-33.

http://journal11.magtechjournal.com/cjcnn/CN/Y2021/V21/I1/30

参考文献

[1] Arjunan A, Peel NM, Hubbard RE. Gait speed and frailty status in relation to adverse outcomes in geriatric rehabilitation[J]. Arch Phys Med Rehabil, 2019, 100:859-864.
[2] Hertz K, Santy-Tomlinson J. Fragility Fracture Nursing:holistic care and management of the orthogeriatric patient[C]. Cham (CH):Springer, 2018:15-26.
[3] Kojima G, Iliffe S, Walters K. Frailty index as a predictor of mortality:a systematic review and meta-analysis[J]. Age Ageing, 2018, 47:193-200.
[4] Liu CH, Hu S, Mao YJ, Xing A. Research progress of frailty[J]. Zhongguo Quan Ke Yi Xue, 2017, 20:2025-2033.[刘长虎,胡松,毛拥军,邢昂.老年人衰弱的研究进展[J].中国全科医学, 2017, 20:2025-2033.]
[5] Vetrano DL, Palmer K, Marengoni A, Marzetti E, Lattanzio F, Roller-Wirnsberger R, Lopez Samaniego L, Rodríguez-Mañas L, Bernabei R, Onder G; Joint Action ADVANTAGE WP4 Group. Frailty and multimorbidity:a systematic review and meta-analysis[J]. J Gerontol A Biol Sci Med Sci, 2019, 74:659-666.
[6] Palmer K, Villani ER, Vetrano DL, Cherubini A, Cruz-Jentoft AJ, Curtin D, Denkinger M, Gutiérrez-Valencia M, Guðmundsson A, Knol W, Mak DV, O'Mahony D, Pazan F, Petrovic M, Rajkumar C, Topinkova E, Trevisan C, van der Cammen TJM, van Marum RJ, Wehling M, Ziere G, Bernabei R, Onder G; European Geriatric Medicine Society Pharmacology special interest group. Association of polypharmacy and hyperpolypharmacy with frailty states:a systematic review and meta-analysis[J]. Eur Geriatr Med, 2019, 10:9-36.
[7] Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA; Cardiovascular Health Study Collaborative Research Group. Frailty in older adults:evidence for a phenotype[J]. J Gerontol A Biol Sci Med Sci, 2001, 56:M146-156.
[8] O'Brien TD, Roberts J, Brackenridge GR, Lloyd WH. Some aspects of community care of the frail and elderly:the need for assessment[J]. Gerontol Clin (Basel), 1968, 10:215-227.
[9] Rockwood K, Mitnitski AB, MacKnight C. Some mathematical models of frailty and their clinical implications[J]. Rev Clin Gerontol, 2002, 12:109-117.
[10] Bouillon K, Batty GD, Hamer M, Sabia S, Shipley MJ, Britton A, Singh-Manoux A, Kivimäki M. Cardiovascular disease risk scores in identifying future frailty:the Whitehall Ⅱ prospective cohort study[J]. Heart, 2013, 99:737-742.
[11] Taylor-Rowan M, Cuthbertson G, Keir R, Shaw R, Drozdowska B, Elliott E, Stott D, Quinn TJ. The prevalence of frailty among acute stroke patients, and evaluation of method of assessment[J]. Clin Rehabil, 2019, 33:1688-1696.
[12] Hébert R, Bravo G, Korner-Bitensky N, Voyer L. Predictive validity of a postal questionnaire for screening community-dwelling elderly individuals at risk of functional decline[J]. Age Ageing, 1996, 25:159-167.
[13] Soong J, Poots AJ, Scott S, Donald K, Woodcock T, Lovett D, Bell D. Quantifying the prevalence of frailty in English hospitals[J]. BMJ Open, 2015, 5:e008456.
[14] Collard RM, Boter H, Schoevers RA, Oude Voshaar RC. Prevalence of frailty in community-dwelling older persons:a systematic review[J]. J Am Geriatr Soc, 2012, 60:1487-1492.
[15] Palmer K, Vetrano DL, Padua L, Romano V, Rivoiro C, Scelfo B, Marengoni A, Bernabei R, Onder G. Frailty syndromes in persons with cerebrovascular disease:a systematic review and Meta-analysis[J]. Front Neurol, 2019, 10:1255.
[16] Sergi G, Veronese N, Fontana L, De Rui M, Bolzetta F, Zambon S, Corti MC, Baggio G, Toffanello ED, Crepaldi G, Perissinotto E, Manzato E. Pre-frailty and risk of cardiovascular disease in elderly men and women:the Pro. V. A. study[J]. J Am Coll Cardiol, 2015, 65:976-983.
[17] Veronese N, Sigeirsdottir K, Eiriksdottir G, Marques E, Chalhoub D, Phillips CL, Launer LJ, Maggi S, Gudnason V, Harris TB. Frailty and risk of cardiovascular diseases in older persons:the age, gene/environment susceptibility-Reykjavik study[J]. Rejuvenation Res, 2017, 20:517-524.
[18] Vetrano DL, Palmer KM, Galluzzo L, Giampaoli S, Marengoni A, Bernabei R, Onder G; Joint Action ADVANTAGE WP4 group. Hypertension and frailty:a systematic review and meta-analysis[J]. BMJ Open, 2018, 8:e024406.
[19] Assar ME, Laosa O, Rodríguez Mañas L. Diabetes and frailty[J]. Curr Opin Clin Nutr Metab Care, 2019, 22:52-57.
[20] Lau LH, Lew J, Borschmann K, Thijs V, Ekinci EI. Prevalence of diabetes and its effects on stroke outcomes:a meta-analysis and literature review[J]. J Diabetes Investig, 2019, 10:780-792.
[21] Seixas AA, Henclewood DA, Williams SK, Jagannathan R, Ramos A, Zizi F, Jean-Louis G. Sleep duration and physical activity profiles associated with self -reported stroke in the United States:application of Bayesian belief network modeling techniques[J]. Front Neurol, 2018, 9:534.
[22] Ferrucci L, Fabbri E. Inflammageing:chronic inflammation in ageing, cardiovascular disease, and frailty[J]. Nat Rev Cardiol, 2018, 15:505-522.
[23] Yarla NS, Polito A, Peluso I. Effects of olive oil on TNF-α and IL-6 in humans:implication in obesity and frailty[J]. Endocr Metab Immune Disord Drug Targets, 2018, 18:63-74.
[24] Samson LD, Boots AMH, Verschuren WMM, Picavet HSJ, Engelfriet P, Buisman AM. Frailty is associated with elevated CRP trajectories and higher numbers of neutrophils and monocytes[J]. Exp Gerontol, 2019, 125:110674.
[25] Shi K, Tian DC, Li ZG, Ducruet AF, Lawton MT, Shi FD. Global brain inflammation in stroke[J]. Lancet Neurol, 2019, 18:1058-1066.
[26] Winovich DT, Longstreth WT Jr, Arnold AM, Varadhan R, Zeki Al Hazzouri A, Cushman M, Newman AB, Odden MC. Factors associated with ischemic stroke survival and recovery in older adults[J]. Stroke, 2017, 48:1818-1826.
[27] Yagi M, Fujita N, Okada E, Tsuji O, Nagoshi N, Tsuji T, Asazuma T, Nakamura M, Matsumoto M, Watanabe K. Impact of frailty and comorbidities on surgical outcomes and complications in adult spinal disorders[J]. Spine (Phila Pa 1976), 2018, 43:1259-1267.
[28] Adams P, Ghanem T, Stachler R, Hall F, Velanovich V, Rubinfeld I. Frailty as a predictor of morbidity and mortality in inpatient head and neck surgery[J]. JAMA Otolaryngol Head Neck Surg, 2013, 139:783-789.
[29] Seib CD, Rochefort H, Chomsky-Higgins K, Gosnell JE, Suh I, Shen WT, Duh QY, Finlayson E. Association of patient frailty with increased morbidity after common ambulatory general surgery operations[J]. JAMA Surg, 2018, 53:160-168.
[30] Isobe N, Ikawa F, Tominaga A, Kuroki K, Sadatomo T, Mizoue T, Hamasaki O, Matsushige T, Abiko M, Mitsuhara T, Kinoshita Y, Takeda M, Kurisu K. Factors related to frailty associated with clinical deterioration after meningioma surgery in the elderly[J]. World Neurosurg, 2018, 119:e167-173.
[31] McIntyre M, Gandhi C, Dragonette J, Schmidt M, Cole C, Santarelli J, Lehrer R, Al-Mufti F, Bowers CA. Increasing frailty predicts worse outcomes and increased complications after angiogram-negative subarachnoid hemorrhages[J]. World Neurosurg, 2020, 134:e181.
[32] Lewis ET, Dent E, Alkhouri H, Kellett J, Williamson M, Asha S, Holdgate A, Mackenzie J, Winoto L, Fajardo-Pulido D, Ticehurst M, Hillman K, McCarthy S, Elcombe E, Rogers K, Cardona M. Which frailty scale for patients admitted via Emergency Department:a cohort study[J]? Arch Gerontol Geriatr, 2019, 80:104-114.
[33] Avila-Funes JA, Pelletier A, Meillon C, Catheline G, Periot O, Trevin O-Frenk I, Gonzalez-Colaço M, Dartigues JF, Pérès K, Allard M, Dilharreguy B, Amieva H. Vascular cerebral damage in frail older adults:the AMImage study[J]. J Gerontol A Biol Sci Med Sci, 2017, 72:971-977.
[34] Chung CP, Chou KH, Chen WT, Liu LK, Lee WJ, Chen LK, Lin CP, Wang PN. Cerebral microbleeds are associated with physical frailty:a community-based study[J]. Neurobiol Aging, 2016, 44:143-150.
[35] Siejka TP, Srikanth VK, Hubbard RE, Moran C, Beare R, Wood A, Phan T, Balogun S, Callisaya ML. Frailty and cerebral small vessel disease:a cross-sectional analysis of the Tasmanian study of cognition and gait (TASCOG)[J]. J Gerontol A Biol Sci Med Sci, 2018, 73:255-260.
[36] Trevisan C, Veronese N, Maggi S, Baggio G, Toffanello ED, Zambon S, Sartori L, Musacchio E, Perissinotto E, Crepaldi G, Manzato E, Sergi G. Factors influencing transitions between frailty states in elderly adults:the progetto veneto anziani longitudinal study[J]. J Am Geriatr Soc, 2017, 65:179-184.
[37] Lee JS, Auyeung TW, Leung J, Kwok T, Woo J. Transitions in frailty states among community-living older adults and their associated factors[J]. J Am Med Dir Assoc, 2014, 15:281-286.

选择文件类型/文献管理软件名称

选择包含的内容

2 衰弱合并脑血管病研究进展

Research progress of frailty complicated with cerebrovascular disease

RichHTML

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	薛蓉, 张轩. 睡眠障碍对脑血管病的影响[J]. 中国现代神经疾病杂志, 2023, 23(8): 659-662.
[2]	张鹏, 陈涛, 许莉. 成人失眠认知行为疗法关键技术与流程改进建议[J]. 中国现代神经疾病杂志, 2023, 23(8): 663-667.
[3]	张轩, 薛蓉. 特发性快速眼动睡眠期行为障碍向神经系统变性疾病转化的生物学标志物研究进展[J]. 中国现代神经疾病杂志, 2023, 23(8): 668-673.
[4]	刘引, 汤永红, 翟锦霞, 邱媛. 慢性低度炎症与睡眠障碍研究进展[J]. 中国现代神经疾病杂志, 2023, 23(8): 674-677.
[5]	于洁洋, 张亚男, 李惠敏, 黄真灿, 李宛儒, 王赞. 发作性睡病与焦虑研究进展[J]. 中国现代神经疾病杂志, 2023, 23(8): 678-682.
[6]	库成心, 邓丽影, 谢亮. 缺血性卒中继发日间过度思睡研究进展[J]. 中国现代神经疾病杂志, 2023, 23(8): 683-686.
[7]	姜佳凤, 赵莲花, 赵伟. 褪黑素在阿尔茨海默病病理损害机制中的作用[J]. 中国现代神经疾病杂志, 2023, 23(8): 687-692.
[8]	黄沛, 王刚. 功能性帕金森综合征诊断与治疗[J]. 中国现代神经疾病杂志, 2023, 23(8): 738-741.
[9]	洪涛, 唐斌. 如何成为一名优秀的颅底外科医师[J]. 中国现代神经疾病杂志, 2023, 23(7): 571-574.
[10]	张庆硕, 宋丹丹, 周世越, 张金璐, 韩晓旭, 许顺良. 功能性步态障碍诊断与治疗[J]. 中国现代神经疾病杂志, 2023, 23(7): 604-609.
[11]	潘希娟, 邢英琦, 刘玉梅. 脑小血管病影像学评分方法[J]. 中国现代神经疾病杂志, 2023, 23(7): 633-637.
[12]	俞淑凤, 李宁, 徐健, 王鹏. 颈动脉漂浮血栓相关缺血性卒中诊断与治疗进展[J]. 中国现代神经疾病杂志, 2023, 23(7): 638-642.
[13]	王建, 李梦娇, 祝俊驰, 陈丽娟, 孔平. Wallenberg综合征合并高血压脑病发病的青年脑卒中一例[J]. 中国现代神经疾病杂志, 2023, 23(7): 648-651.
[14]	魏俊吉. 神经外科重症医学规范化诊断与治疗[J]. 中国现代神经疾病杂志, 2023, 23(6): 477-478.
[15]	杜倩, 邓素君, 邹姗, 金珺, 周青山. 宏基因组第二代测序技术在重症中枢神经系统感染中的应用[J]. 中国现代神经疾病杂志, 2023, 23(6): 479-484.

模态框（Modal）标题

选择文件类型/文献管理软件名称

选择包含的内容

2 衰弱合并脑血管病研究进展

Research progress of frailty complicated with cerebrovascular disease

RichHTML

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价