中国现代神经疾病杂志 ›› 2021, Vol. 21 ›› Issue (1): 25-29. doi: 10.3969/j.issn.1672-6731.2021.01.006

• 脑卒中研究进展 • 上一篇    下一篇

2 脑小血管病血流动力学损害研究进展

刘娜1, 薛扬1, 唐杰1, 张苗怡2, 任雪1, 付建辉1   

  1. 1 200040 上海,复旦大学附属华山医院神经内科;
    2 201907 上海,复旦大学附属华山医院北院神经内科
  • 收稿日期:2021-01-11 出版日期:2021-01-25 发布日期:2021-01-22
  • 通讯作者: 付建辉,Email:jianhuifu@126.com
  • 基金资助:

    国家自然科学基金资助项目(项目编号:81671151);上海市科学技术委员会科研计划项目(项目编号:18411962100)

Research progress of impaired cerebral hemodynamics in cerebral small vessel disease

LIU Na1, XUE Yang1, TANG Jie1, ZHANG Miao-yi2, REN Xue1, FU Jian-hui1   

  1. 1 Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China;
    2 Department of Neurology, North Huashan Hospital, Fudan University, Shanghai 201907, China
  • Received:2021-01-11 Online:2021-01-25 Published:2021-01-22
  • Supported by:

    This study was supported by the National Natural Science Foundation of China (No. 81671151) and Scientific Research Program of Shanghai Municipal Science and Technology Commission (No. 18411962100).

摘要:

脑血流动力学损害是小动脉硬化型脑小血管病发病机制的重要环节,包括血压变异性升高、血管搏动性改变、脑血流量降低等,并可能通过加重内皮功能障碍、血-脑屏障破坏等使疾病进展加快。本文对小动脉硬化型脑小血管病血流动力学损害进展进行综述。

关键词: 大脑小血管疾病, 血流动力学, 综述

Abstract:

Cerebral hemodynamic damage is an important mechanism in the pathogenesis of arteriolosclerotic cerebral small vessel disease (CSVD). The hemodynamic damage of cerebral small vessel disease includes the changes of blood pressure variability (BPV), vascular pulsatility, cerebral blood flow (CBF) and so on. Impaired cerebral hemodynamics may promote the progression of the disease by aggravating the damage of endothelial dysfunction and the disruption of blood-brain barrier (BBB). This paper reviews progress of impaired cerebral hemodynamics in arteriolosclerotic cerebral small vessel disease.

Key words: Cerebral small vessel diseases, Hemodynamics, Review