脑淀粉样血管病相关炎症研究进展

doi:10.3969/j.issn.1672-6731.2020.09.002

摘要/Abstract

摘要：

脑淀粉样血管病相关炎症（CAA-I）是脑淀粉样血管病的罕见亚型，逐渐受到临床医师的关注。CAA-I组织病理学兼具脑淀粉样血管病和血管炎的特点；临床主要表现为认知功能减退、癫发作、头痛等，具有较大的临床异质性；头部MRI检查是临床诊断及评估疗效的重要手段，可见T₂WI和FLAIR成像脑白质高信号病灶和多发脑微出血灶；免疫抑制治疗反应良好，与脑淀粉样血管病有一定差异。本文拟就CAA-I病因和病理生理学机制、病理学特点、临床表现、辅助检查、治疗等方面研究进展进行综述。

关键词: 脑淀粉样血管病, 血管炎, 中枢神经系统, 免疫疗法, 综述

Abstract:

Cerebral amyloid angiopathy associated with inflammation (CAA-I) is a rare subtype of cerebral amyloid angiopathy (CAA), and is increasingly recognized by neurologists. CAA-I is characterized by the pathological hallmarks of both CAA and vasculitis. The main clinical manifestations contain cognitive decline, seizures, headaches and so on, which present great clinical heterogeneity. Cranial MRI plays an important role in the diagnosis and evaluation of CAA-I, by which white matter hyperintensity (WMH) and multiple cerebral microbleeds (CMBs) could be usually found. CAA-I responds well to immunosuppressive therapy. All the characteristics above are different from CAA somehow. This paper aims to review the advances in pathophysiology, pathology, clinical manifestations, laboratory examination and treatment of CAA-I.

Key words: Cerebral amyloid angiopathy, Vasculitis, central nervous system, Immunotheraphy, Review

张文浩, 刘冉, 黄一宁. 脑淀粉样血管病相关炎症研究进展[J]. 中国现代神经疾病杂志, 2020, 20(9): 760-765.

ZHANG Wen-hao, LIU Ran, HUANG Yi-ning. Research progress of cerebral amyloid angiopathy associated with inflammation[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2020, 20(9): 760-765.

http://journal11.magtechjournal.com/cjcnn/CN/Y2020/V20/I9/760

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